Table S1. The DR-affecting nsSNVs in the DrugVar dataset. rsID Gene Variant Drug GSTP1 RefSeq_ Protein NP_000843 rs1695 I105V rs4680 rs4880 rs4961 rs20455 rs25487 rs396991 rs1042522 COMT SOD2 ADD1 KIF6 XRCC1 FCGR3A TP53 NP_000745 NP_000627 NP_001110 NP_659464 NP_006288 NP_000560 NP_000537 V158M V16A G460W W719R Q399R F212V P72R rs1042713 rs1050828 rs1056892 rs1057910 ADBR2 G6PD CBR3 CYP2C9 NP_000015 NP_000393 NP_001227 NP_000762 G16R V98M V244M I359L rs1127354 rs1142345 ITPA TPMT NP_258412 NP_000358 P32T Y240C rs1799971 rs1800460 OPRM1 TPMT NP_000905 NP_000358 N40D A154T rs1800497 ANKK1 NP_848605 E713K rs1801019 rs1801131 UMPS MTHFR NP_000364 NP_005948 G123A E429A rs1801133 MTHFR NP_005948 A222V rs1801394 rs2228001 rs2231142 rs2297595 rs3212986 rs3745274 rs4149056 rs67376798 rs75527207 rs121434568 MTRR XPC ABCG2 DPYD ERCC1 CYP2A7P1 SLCO1B1 DPYD CFTR EGFR NP_002445 NP_001139241 NP_004818 NP_000101 NP_036231 NP_000758 NP_006437 NP_000101 NP_000483 NP_005219 I22M Q902K Q141K M166V Q504K Q172H V174A D949V G551D L838R rs121434569 EGFR NP_005219 T790M Platinum compounds, fluorouracil, oxaliplatin, cyclophosphamide, epirubicin Nicotine Cyclophosphamide Furosemide, spironolactone Pravastatin Carboplatin, cisplatin, oxaliplatin, platinum compounds Rituximab, cetuximab Antineoplastic agents, cisplatin, cyclophosphamide, fluorouracil, paclitaxel Salbutamol, salmeterol Chlorproguanil, dapsone anthracyclines and related substances Warfarin, antiinflammatory agents, non-steroids, celecoxib, diclofenac, acenocoumarol interferon alfa-2b recombinant, ribavirin Azathioprine, mercaptopurine, purine analogues, thioguanine Ethanol, morphine, naloxone Azathioprine, mercaptopurine, purine analogues, thioguanine Bupropion, antipsychotics, antipsychotics, clozapine, olanzapine, risperidone, ethanol Fluorouracil, leucovorin, tegafur Capecitabine, fluorouracil, leucovorin, oxaliplatin, capecitabine Methotrexate, fluorouracil, carboplatin, cyclophosphamide methotrexate cisplatin rosuvastatin Capecitabine, fluorouracil Cisplatin, platinum compounds efavirenz Simvastatin, cerivastatin, hmg coa reductase inhibitors fluorouracil ivacaftor Erlotinib, gefitinib, carboplatin, gefitinib, paclitaxel, carboplatin, docetaxel, erlotinib, gemcitabine, paclitaxelefitinib Erlotinib, gefitinib