Publication of the Bureau of Epidemiology & Disease Control Service September/October 2002, Vol. 16, No. 5 Statewide Strategy Well Under Way For Bioterrorism Preparedness By David Engelthaler and Powell Gammill The anniversary of September 11th is already here, and the Arizona Department of Health Services is moving rapidly forward with the development of its statewide strategy for bioterrorism preparedness. public health officials, first responders, and federal partners, are currently testing the system. The SIREN system has received national attention and has become a model for other states to follow. Federal grants were also recently awarded to all states to coordinate hospital bioterrorism preparedness. The Department has already coordinated several state-wide and regional meetings to address the planning and assessment needs of the hospitals in the state. These assessments will be used to prioritize the hospitals’ preparedness needs. Public Health Preparedness The Centers for Disease Control and Prevention has provided funding to all states, including Arizona, to further public health preparedness and to build a solid public health infrastructure. The Department is focusing on the following areas of public health preparedness: emergency response planning; enhanced disease surveillance; increased laboratory capabilities; secure web-based health alert network; risk communication; and bioterrorism education and training for healthcare providers. Recently all county health departments were awarded grants to develop and meet these capacities as well. Of particular note, the Department has recently developed the SIREN (Secure Integrated Response Electronic Notification) system. This system is designed to share health alerts and other sensitive information over a high-speed, highly secure, web-based environment. Over 100 users in the state, including Laboratory Readiness Staffing has been increased at the State Public Health Laboratory to respond to the increasing need for public health preparedness. The increased personnel will soon the State Laboratory to provide seven days per week capability for responding to suspect bioterrorism incidents and other potential epidemics. Clinical laboratories and other partners in the state will be notified of when this expanded coverage will start. Real-time Polymerase Chain Reaction (PCR) capacities and other rapid molecular and antigen detec- tion methods will be expanded to cover the increasing need for swift presumptive testing. The State Laboratory is boosting its testing capacity, upgrading testing methodologies and expanding environmental sampling to include improved food-borne illness surveillance. Throughout the state, bioterrorism laboratory personnel have conducted training in more than 30 private clinical laboratories to recognize and safely rule out certain priority biological agents. On-site and off-site training will continue for all clinical laboratories in the state. Continued on page 8 Visit the ADHS Web site at www.hs.state.az.us Influenza Season Approaching Page 2 September/October 2002 Bacteria Leave “Fingerprint” Page 3 Adverse Health Effects of Fire Page 4 Breast Cancer Study Update Page 5 Antibiotic Resistance Campaign Page 6 Summary Chart of Reportable Diseases Page 7 Prevention Bulletin 1 Influenza Season is Rapidly Approaching By Anne Lutz If the 2002-2003 Arizona influenza season follows the same pattern as last year, the first influenza case will be detected in November and the number of cases will peak by early February and begin to decline by mid-March. Projected influenza vaccine production for this year is between 92 and 97 million doses. The Advisory Committee on Immunization Practices (ACIP) has published their recommendations for the 2002-03 flu season which includes the optimal timing for highrisk groups and for those who are not at risk of complications from the flu. The special needs of young children for the flu vaccine have also been addressed. These guidelines can be found at the CDC influenza website http://www.cdc.gov/nip/flu. It is recommended that vaccinations begin for the following groups in October: High Risk of Severe Illness • 65 years old or older • Children 6 - 23 months old • Adults and children with a chronic health condition • More than 3 months pregnant during the flu season Can Give Flu to Those at High Risk • Household contact or care-giver of someone at high risk • Health care workers • Household contact or care-giver of a child under 2 years old A Child’s Very First Flu Shot • Children 6 months to 8 years old who are getting the first flu shot need a booster shot one month after the first dose of vaccine. All other persons should be vaccinated beginning in November. Vaccination should continue through December and beyond. Influenza vaccine for the 2002-03 influenza season is still available for purchase. Health care providers who have not ordered influenza vaccine should do so as soon as possible to ensure timely receipt of vaccine. In general, providers who ordered vaccine directly from the manufacturers received the vaccine earlier. Vaccine prices have risen again from about $5 per dose last year to $6.50 per dose this season. Anne Lutz is the Adult Immunization Coordinator for the Arizona Immunization Program. She can be reached at 602.230.5837 or alutz@hs.state.az.us. FLU HOTLINES Following is a listing of flu vaccine clinic hotlines that will begin in October. • Community Information and Referral Flu Hotline Metro Phoenix: 602-263-8856 Outlying Areas: 800-352-3792 www.cir.org • Southern Arizona Information and Referral 520-881-1794 www.azinfo.org • Basha's Healthstyles 480-895-5350 • The Mollen Clinic 602-277-3588. www.mollen.com • Healthwaves, Inc. 480-968-1886. www.healthwaves.com • Maxim Health Care 1-888-436-3339 www.maximflu.com Influenza in Arizona 1995-2001 Figure 1 Definitions Sporadic Activity • Influenza cases, either laboratoryAverage influenza season activity confirmed or influenza-like illfrom 1995-2000. ness (ILI), are reported; however, reports of outbreaks in places 2000-2001influenza season activity. such as schools, nursing homes, and other institutional settings have not been received. Regional Activity • Outbreaks of either laboratoryconfirmed or ILI are occurring in geographic areas containing less than 50% of the state’s population. A geographic area could be a city, county, or district. Widespread Activity • Outbreaks of either laboratoryconfirmed or ILI are occurring in geographic areas representing more than 50% of the state’s population. 2 Prevention Bulletin September/October 2002 Even Bacteria Leave a “Fingerprint” Victor Waddell, Ph.D, and Graham Briggs Foodborne illness and death isms supplied by CDC with known resulting from microorganisms are a fingerprints as standards. By running a To stop the potential common and preventable public known standard organism on every health problem. It has been estimated PFGE gel, a computerized software spread of a foodborne that over 80 million cases of foodprogram can standardize each gel outbreak, it is imperative borne and water borne illnesses and allow comparison of fingerprints that the source of the occur in the United States each year from PFGE gels from different states. resulting in as estimated 9,000 deaths. PulseNet's electronic database microorganism is Over 1,800 cases of salmonellosis, enables microbiologists throughout quickly found. shigellosis, and camphylobacteriosis the U.S. to compare bacterial fingeroccurred in Arizona in 2001. The print patterns with those from other more recently recognized pathogen, E. bacterial species. The lab can help states and to determine if there may coli O157:H7, accounted for 30 cases determine if the cases are related by be a common outbreak pattern. This of illness in 2001. looking for a common bacterial finsummer, over 19 million pounds of To stop the potential spread of a gerprint among the patient isolates. ground beef was recalled from numerfoodborne outbreak, it is imperative This information can then be used to ous states due to E. coli O157:H7 that the source of the microorganism connect patients to a common bactecontamination. The State Lab is comis quickly found. The State Laboratory rial source. paring all samples of E. coli that are now has the ability to genetically “finBecause foodborne outbreaks received for association with any of gerprint” organisms using a procedure associated with a common source the E. coli responsible for the beef known as Pulsed Field Gel often occur in multiple states, the recall. In addition, the State Electrophoresis (PFGE). Most species Centers for Disease Control and Laboratory routinely compares the of bacteria can be categorized into Prevention (CDC) has created a labobanding patterns of Salmonella and several sub-types by PFGE depending ratory network called PulseNet. All other organisms that are isolated to on the amount of genetic variation in 50 states and the CDC participate in statewide and national outbreaks. that particular species and the restricthis program. The CDC publishes standardized tion enzyme used. PulseNet allows standardization protocols for all participating laboratoThe State Laboratory can perform and coordination of laboratory results ries. Currently, the Arizona State PFGE with just a couple of isolated on a multistate level when common Laboratory has standardized protocols colonies grown on a nutrient agar source outbreaks occur. Images of for E. coli, Salmonella, Listeria monoplate. By using a rare cutting restricPFGE gels can be analyzed and forcytogenes, Shigella, Clostridium pertion enzyme, the lab can cut the warded to CDC through e-mail for fringens, Campylobacter, and Vibrio. entire bacterial chromosome into comparison in a national database. However, the State Laboratory can twenty to thirty pieces. These pieces of Standardization of results among difalso fingerprint Enterococcus, DNA, or bands, can then be separated ferent laboratories is accomplished Enterobacter, Staphylococcus, by their molecular weight using through the use of sub-types of organStreptococcus, Pseudomonas, agarose gel electrophoresis. The Legionella and others upon request difference in size of bands and by state epidemiologists. Figure 1 number of restriction sites allows Bacterial “fingerprints” don’t the lab to differentiate between provide the finality of a human finclosely related and identical bacgerprint. While each human has a terial sub-types from more genetiunique fingerprint, clones of bactecally divergent isolates. An identiria all have identical “fingerprints”. cal sub-type isolated from both Although each bacteria may not food and persons who had conleave an actual unique fingerprint, sumed the contaminated food can they do leave a trail for epidemiolobe a valuable piece of evidence gists to follow. for epidemiologists as they investiVictor Waddell, Ph.D., is Chief of the Office of gate an outbreak. Microbiology at the State Lab and can be PFGE can also be a valuable reached at 602.542.2897 or vwaddel@hs.state.az.us. Graham Briggs is a analytical tool to evaluate an Public Health Scientist with the State Lab and increase in hospital clinical infecShows the genetic variation in E. coli O157:H7 can be reached at 602.542.6132 or tions being caused by the same sub-types after performing PFGE. gbriggs@hs.state.az.us. September/October 2002 Prevention Bulletin 3 Adverse Health Effects Associated With The Rodeo-Chediski Fire A public health survey of more than 400 residents affected by the Rodeo-Chediski fire found widespread stress and health problems among both evacuees and those who did not evacuate. The Arizona Department of Health Services, the federal Centers for Disease Control and Prevention, and the Navajo County Health Department conducted the survey in southern Navajo County between July 5 and July 9. More than 40 percent of those interviewed reported “a lot” or a “significant” amount of stress, and more than 40 percent felt that smoke from the fires had harmed their health. Preliminary findings showed that: • One-third of all respondents reported experiencing at least one health symptom including cough, shortness of breath, sore throat, chest pain, eye irritation or increased allergies from the smoke. Stress levels were generally higher in people that were evacuated. • Working people reported losing approximately four days of work because of the fire. • Sixty-six percent of asthmatics reported that their symptoms were worse after the fire. • Asthma symptoms were generally worse in people that did not evacuate or were in non-evacuated areas. The findings that smoke from the fire caused respiratory problems are consistent with other epidemiologic studies that have found exposure to particulate matter less than 10 microns in size causes shortness of breath, increases in coughs, aggravation of asthma, decreases in lung function and lung defense mechanisms, chronic obstructive pulmonary disease, and By Will Humble • Photo courtesy of the East Valley Tribune increased rates of hospitalization for respiratory and cardiovascular illnesses. The concentrations of particulate matter measured by portable monitors established that the levels were certainly high enough to cause adverse health effects. Continued on page 6 Most Deaths from Fire are Preventable During the past decade an average of 44 Arizona residents each year died due to fire, flames, or smoke. Most of these deaths occurred in a residential setting. Smoke alarms, if functional, are highly effective in preventing deaths from residential fires. However, Arizona survey data found that only 24.6% of adults with a residential smoke detector said they had checked it within the past month (Behavioral Risk Factor Survey, 1998). Health care providers should encourage patients to install a smoke detector in each sleep area, and to test the alarm monthly. The National Fire Protection Association (www.NFPA.org) urges that batteries in battery-powered alarms be replaced yearly, and that alarms should be replaced every 10 years. 4 Prevention Bulletin Figure 1 Accidental (unintentional injury) deaths from fire and flame among Arizona residents. Source: ADHS Vital and Health Statistics Report, 2000. September/October 2002 Noteworthy... “Dr. Bob” to Re-join ADHS as State Epidemiologist A former member of the public health team at the Arizona Department of Health Services will be re-joining the staff this fall, assuming his previous position as Arizona’s State Epidemiologist. Bob England, M.D., M.P.H., better known among colleagues as “Dr. Bob” was formerly employed in the position from 1996 to 1999, where he was involved in a variety of public health achievements. “We are very lucky to have Dr. England back at the Department,” said Catherine Eden, Director. “His depth of education and professional experience will greatly assist our efforts in dealing with the emerging challenges facing public health, such as bioterrorism and emerging infectious diseases.” As State Epidemiologist, Dr. England’s responsibilities will include coordinating disease control and surveillance activities in the state, working closely with county health offices, and assisting the Director in representing departmental and public health concerns to the media, legislature, other agencies and policy makers. He will join the Department in October. Dr. England left Arizona in April 1999 for his current position as Director of the Health Department in Milford, Conn. His accomplishments in Milford include the design and management of a surveillance-based hepatitis C intervention program for several local health departments, implementing a community-based health education program with youth peer educators, and community-wide oral health planning. Dr. England received his M.D. from the University of Arizona College of Medicine and a Master’s in Public Health at the UCLA School of Public Health. He holds physician licenses in Arizona and Connecticut, and is Board Certified in Public Health and General Preventive Medicine. September/October 2002 Prior to serving as the Department’s State Epidemiologist, he served as Medical Director for Preventive Medical Health Services at the Maricopa County Department of Public Health Services, Medical Director for Clinica Adelante in Surprise, Arizona, and Division Director for the Disease Control Division of the Pima County Health Department. Breast Cancer Study Update A study called SHINE (Southwest Hormone, Insulin, Nutrition and Exercise) began in January to determine if there are associations between metabolic, genetic, and environmental factors that may affect the risk of developing breast cancer. Using information supplied by the Arizona Cancer Registry, the University of Arizona Cancer Center will survey approximately 1,200 randomly chosen Native American, Hispanic, and White women diagnosed with breast cancer between 2000 and 2003. This study is being conducted in Arizona, New Mexico, Utah, and Colorado. (See July/August 2001 issue of Prevention Bulletin.) As of August 1, 2002, approximately 400 physicians have given permission for their patients to be contacted for participation in this study. Over 200 physicians have given blanket permission to contact all of their patients. Study staff have contacted 156 patients and completed 99 surveys. The response by Arizona’s physi- cians is greatly appreciated. Physicians are encouraged to inform their breast cancer patients that they may be contacted to participate in this important study. To reach the Arizona Cancer Registry field office, please call Daniel Garcia at 480.947.3972. The University of Arizona study coordinator, Tara Patton, can be reached at 520.318.7281. Arizona Case of Hantavirus Reported The Arizona Department of Health Services confirmed in June the first case of Hantavirus Pulmonary Syndrome (HPS) this year in Arizona in a Maricopa County resident. Since 1993, when hantavirus was first identified in the southwest a total of 35 cases of HPS have been reported in Arizona. One case was reported in Arizona last year. HPS is an often deadly disease that usually begins with flu-like symptoms, and may rapidly progress to respiratory failure when the lungs fill with fluid. Patients usually develop breathing difficulty approximately two to six days after onset of symptoms. Hantavirus is spread by the deer mouse and other closely-related species of wild mice, which excrete the virus in their urine, droppings and saliva. People can become infected by inhaling particles of the virus that may become airborne when rodent droppings or nests are disturbed. The virus is not spread from person to person. Nationwide, more than 325 cases of HPS have been reported in 31 states since the virus was first recognized. Of these, approximately 35 percent were fatal. The disease was first recognized during a 1993 outbreak that occurred in the Four Corners area, affecting 53 people in Arizona, Utah, New Mexico and Colorado. Hantavirus can occur wherever the deer mouse and its close relatives are present, which includes most rural areas throughout the state. Other Continued on page 8 Prevention Bulletin 5 Strike Out Antibiotic Resistance Although some diseases have been conquered through major advances in science, public health, and technology, new infectious diseases continue to emerge, while others reemerge in drug-resistant forms. The Centers for Disease Control and Prevention have stated that the emergence of drug resistance in bacteria, parasites, viruses and fungi is swiftly reversing advances of the previous 50 years (www.cdc.gov/ncidod/ emergplan/3executive.htm). Prevention and control of drug-resistant infections hinges upon the judicious use of antimicrobial drugs. In the first pitch of a public health educational campaign, Governor Hull proclaimed September as “Antibiotic Resistance Awareness Month”. The hit of the campaign was an antibiotic resistance poster contest for Arizona school children that was sponsored in part by the Arizona Diamondbacks and the Pediatric Foundation of Arizona, Inc. Mary-Lynn Piper, a 6th-grader from Litchfield Elementary School, made the winning pitch with her “Strike Out Antibiotic Resistance” poster. For a free copy of this campaign winning poster, contact Clare Kioski at 602.230.5927 or ckioski@hs.state.az.us. Recommendations for appropriate antibiotic use for health care providers: • Only prescribe antibiotic therapy when likely to be beneficial to the patient. • Use an agent targeting the likely pathogens. • Use the antibiotic for the appropriate dose and duration. • Educate patients on the appropriate use of antibiotics and the importance of prevantative measures, such as handwashing. Fire – Continued from page 4 However, the long-term public health impact from the fire may be more insidious. Increases in substance abuse, domestic violence, and other mental health problems are often the consequences of stress that follows disasters such as the RodeoChediski fire. Unfortunately, persons in the most need of counseling and other mental and behavioral health services are often the least likely to seek them out. The Arizona Department of Health Services has received a grant from the Federal Emergency Management Agency to develop behavioral health programs and counseling services in the affected 6 Prevention Bulletin communities. A 24-hour hotline, 1.800.640.2123, is now being provided through the Department’s Northern Arizona mental health contractor, the Northern Arizona Regional Behavioral Health Authority. Any of your patients who were impacted by the fire that you suspect may benefit from professional counseling or other behavioral health services should be encouraged to call the toll-free counseling hotline. Photo courtesy of the East Valley Tribune Will Humble is the Chief of the Office of Environmental Health and can be reached at 602.230.5941 or whumble@hs.state.az.us. September/October 2002 SUMMARY OF SELECTED REPORTABLE DISEASES (January - July, 2002)1 Jan - July 2002 Jan - July 2001 5 Year Median Jan - July 3 (1) 0 1 40 (27) 0 (0) 5 (1) 0 2 302 (120) 0 (0) 5 (3) 0 3 37 (25) 1 (0) 387 16 9 327 180 342 17 6 348 229 293 18 7 357 234 202 141 632 3 2521 254 98 1013 9 2151 463 113 * 12 * 567 207 15 20 581 112 37 13 468 118 18 33 8612 2076 112 (8) 8604 2349 87 (17) 7342 2349 103 (15) 6 (0) 599 5 (0) 437 7 (1) 485 1 0 89 1 0 95 2 0 35 1932 109 212 238 138 (127) 20 907 112 297 331 127 (106) 9 907 123 230 331 206 (106) 8 VACCINE PREVENTABLE DISEASES: Haemophilus influenzae, serotype b invasive disease (<5 years of age) Measles Mumps Pertussis (<12 years of age) Rubella (Congenital Rubella Syndrome) FOODBORNE DISEASES: Campylobacteriosis E.coli O157:H7 Listeriosis Salmonellosis Shigellosis VIRAL HEPATITIDES: Hepatitis A Hepatitis B Hepatitis B: non-acute2 Hepatitis C Hepatitis C: non-acute3 INVASIVE DISEASES: Streptococcus pneumoniae Streptococcus Group A Streptococcus Group B in infants <30 days of age Meningococcal Infection SEXUALLY TRANSMITTED DISEASES: Chlamydia Gonorrhea P/S Syphilis (Congenital Syphilis) DRUG-RESISTANT BACTERIA: TB isolates resistant to at least INH (resistant to at least INH & Rifampin) Vancomycin resistant Enterococci isolates VECTOR-BORNE & ZOONOTIC DISEASES: Hantavirus Pulmonary Syndrome Plague Animals with Rabies ALSO OF INTEREST IN ARIZONA: Coccidioidomycosis Tuberculosis HIV AIDS Lead Poisoning (<16 years of age) Pesticide Poisoning4 1 2 * 4 Data are provisional and reflect case reports during this period except Lead Poisoning which is by date of diagnosis. These counts reflect the year reported or tested and not the date infected. Case counts for non-acute Hepatitis B and C are not available before 1998. Not all reports will be confirmed as meeting the case definition for pesticide poisoning upon further investigation. September/October 2002 Prevention Bulletin 7 ❍ Change of Address/Name ❍ Delete my name from your mailing list ❍ I received more than one copy Please include your mailing label with all requests for changes. Fax changes to 602.230.5959 PRSRT STD US Postage PAID Phoenix, AZ Permit No. 957 Arizona Department of Health Services Public Information Office 3815 North Black Canyon Hwy. Phoenix, AZ 85015 602.230.5901 • Fax 602.230.5959 Jane Dee Hull, Governor Catherine R. Eden, Ph.D., Director ADHS Lee A. Bland, Chief, Bureau of Epidemiology and Disease Control Services Editorial Board Victorio Vaz, D.V.M., Ph.D., Acting State Epidemiologist Tim Flood, M.D. Kathy Fredrickson, M.P.H. Will Humble, M.P.H. Ken Komatsu, M.P.H. Cheryl McRill, M.D. Wesley Press, M.S. Emma N. Viera, M.P.H. Managing Editor: Courtney Casillas e-mail: ccasill@hs.state.az.us Contributors: Graham Briggs, David Engelthaler, Tim Flood, Powell Gammill, Will Humble, Clare Kioski, Anne Lutz, Victor Waddell This publication is supported by the Preventive Health and Health Services Block Grant from the Centers for Disease Control and Prevention (CDC). Its contents do not necessarily represent the views of the CDC. If you need this publication in alternative format, please contact the ADHS Public Information Office at 602.230.5901 or 1.800.367.8939 (State TDD/TTY Relay). Hantavirus – Continued from page 5 rodents, such as roof rats, have not been shown to pose a threat of hantavirus. It is important to take preventive measures to avoid contracting the disease. “The best defense against infection with hantavirus is to avoid cleaning or disturbing areas with recent rodent infestation including nests and droppings,” said Dr. Mira Leslie, State Public Health Veterinarian. “If you do have to clean up droppings or nests, be sure to thoroughly disinfect the area first. Be especially cautious when entering a structure, such as a summer cabin, that has been closed up. People who have been exposed to rodent droppings and who become ill with HPS-like symptoms should seek medical care.” For more information about HPS, contact the ADHS Vector-Borne & Zoonotic Disease Section at 602.230.5820. 8 Prevention Bulletin Bioterrorism – Continued from page 1 We’ve come a long way • A state-wide bioterrorism and Arizona has made great gains in epidemic training program that the arena of public health preparedcoordinates all bioterrorism relatness, but there is still a long way to ed training for physicians and go. The Department’s vision of the other health care providers State’s bioterrorism program These new bioterrorism initiaincludes: tives, although borne • A thoroughly of unspeakable The Centers for Disease Control integrated maliciousness, are and Prevention has provided bioterrorism funding to all states, including nonetheless an exciting response system, Arizona, to further public health and vitalizing venture preparedness and to build a solid from the local for public health, a public health infrastructure. to the federal public service whose levels; role has long been • An electronic, web-based, statemisunderstood or ignored. The wide disease reporting system, Department looks forward to workthat allows for highly secure ing with health care providers across and near real-time disease and the state as we endeavor to achieve outbreak surveillance; public health preparedness. • SIREN as the medium for David Engelthaler is with the Department’s Office all emergency health of Bioterrorism and Epidemic Preparedness and communications Response, and can be reached at 602.230.5920 or dengelt@hs.state.az.us. Powell Gammill is • A laboratory system to rapidly Manager of the Epidemic Detection and Response analyze selected suspicious Section at the State Lab and can be reached at biological samples 602.542.6134 or pgammil@hs.state.az.us September/October 2002