1 INVASIVE HAEMOPHILUS INFLUENZAE DISEASE IN MARICOPA COUNTY January 1, 2000-December 31, 2007 Office of Epidemiology Division of Disease Control Maricopa County Department of Public Health March 2010 *This report is generated from Invasive Haemophilus influenzae Disease Data in Maricopa County 2000-2007, completed 3/4/10 by Benita McKinney. For questions please contact Benita McKinney at mckinneb001@mail.maricopa.gov or Vjollca Berisha at vjollcaberisha@mail.maricopa.gov 2 TABLE OF CONTENTS Overview of Invasive Haemophilus influenzae…………….…………… 3 Haemophilus influenzae Surveillance in Maricopa County……..…… 7 Case Investigations Methodology………………………………………………………. 8 Case Investigation Procedure……………………………………………………………. 10 Epidemiologic Trends in Maricopa County 2000-2007……………….. 12 Seasonality………………………………………………………………………………………... 12 Distribution by Serotype……………………………………………………………………... 13 Case Demographics………………………………………………………………………….. 5 Outcome……………………………………………………………………………………..… 17 Vaccinations…………………………………………………………………………………….. 20 Haemophilus influenzae serotype b……………………………………………………. 20 Haemophilus influenzae Data Quality in Maricopa County 20002007………………..……….……………………………………………………... 23 Investigation Timeliness in Maricopa County 2000-2007..………… 24 Current and Future Research ……………………………………………… 24 Conclusions………………………………………………………………………. 25 Appendix…………………………………………………………………………. 27 A. Seasonality of H. influenzae for years 2000-2007………………………… 28 B. Cases & Deaths of H. influenzae in MC by Serotype, 2000-2007 per year………………………………………………………………………………… 29 C. Cases & Deaths of H. influenzae in MC by Race/Ethnicity, 2000-2007, per year…………………………………………………………………………………. 33 D. Cases & Deaths of H. influenzae MC by Gender, 2000-2007, per year…………………………………………………………………… 37 E. Cases & Deaths of H. influenzae in MC by Agegroup, 2000-2007, per year…………………………………………………………………………………... 40 F. Population Estimates for MC, 2000-2007……………………………………….. 44 G. US Population Estimates for 2000-2007……………………………………….. 54 References…………………………………………………………………………. 55 3 Purpose of the Report The following is a descriptive report of invasive Haemophilus influenzae cases as reported to the Maricopa County Department of Public, Division of Disease Control, Office of Epidemiology during the years 2000-2007. The report will encompass the following: • A brief overview of the Haemophilus influenzae bacterium and its characteristics • Methodology • Case demographics, serotype data, and disease trends • A discussion addressing data quality and timeliness of reporting The purpose of this report is twofold: first to define the illness and its trends in Maricopa County during this time period and second to identify potential areas of improvement in data quality. Overview of Haemophilus influenzae Etiologic Agent Haemophilus influenzae is a gram negative coccobacilli bacterium which is characterized as being capsulated or unencapsulated. Among the organisms having a polysaccharide capsule there are six serotypes designated as a-f with serotype b being the most clinically significant. Unencapsulated organisms, those not having a polysaccharide capsule, are categorized as non-typeable. Figure1. Haemophilus influenzae bacterium 4 Clinical Description Haemophilus influenzae disease manifests within various locations in the body causing infections such as the more prevalent bacteremia, meningitis, epiglottitis, and pneumonia to the less prevalent endocarditis. In the United States complications from Haemophilus influenzae type b (Hib) include fatalities in 3-6% of the cases and as many as 20% of the cases have permanent hearing damage or other long term health concerns (Centers for Disease Control and Prevention [CDC], 2008). Symptoms of H. influenzae infections are generalized and dependent upon where it has manifested in the body. The generalization of symptoms may present obstacles to diagnosing the disease. Although, Hib is the most clinically significant, the other serotypes are just as adept at causing illness. Reservoirs The reservoir for this organism is the human respiratory tract. During the pre-vaccine era, the organism could be isolated from the nasopharynx of children that were often asymptomatic indicating colonization rather than infection. A recent study concluded that infants who are immunized are less likely to become colonized than those who have not been immunized. The authors determined that an association existed between levels of serum antibodies against Hib and the likelihood of being colonized (Fernandez, J., Levine, O., Sanchez, J., Balter, S., LaClaire, L., & Feris, J., 2000). Modes of Transmission The mode of transmission occurs via person to person through nasopharyngeal droplets or direct contact with respiratory tract secretions. Entry into uninfected individuals occurs through the nasopharynx as a result of contact with nasopharyngeal droplets of an infected person or one who is a carrier. Contact includes the sharing of utensils, coughing or kissing. Incubation Period and Period of Communicability The symptoms of H. influenzae usually occur within one to four days after exposure (American Academy of Pediatrics, 2006). Conclusive secondary attack rates have not been established for either household members or children that attend daycare. 5 Epidemiology The World Health Organization ([WHO], 2005) reports that worldwide Haemophilus influenzae type b (Hib) is responsible for approximately 3 million cases and 386,000 deaths. These cases primarily occur in developing countries where the disease is not readily recognized, antibiotic treatment is scarce and a vaccine is not available. WHO (2008) reports that as of 2007, many African and Asian countries still do not have an available Hib vaccine. The vaccine was first used in the United States in 1988. The first vaccine was licensed for children 18-59 months old and two years later the second vaccine was licensed for use in infants. During the nine years following the initiation of Hib vaccinations the incidence in children less than five years old declined by 99% (CDC, 1998) from 34 per 100,000 (CDC, 1998) to the current rate of 1 case per 100,000 in children less than five years old (CDC, 2008). New standards established in CDC’s Healthy People 2010 indicate that the goal is to eliminate infections in children under the age of five years old by creating a herd immunity effect. The Centers for Disease Control and Prevention is monitoring the progress of this goal by performing enhanced surveillance in ten states representing approximately 36 million individuals (CDC Active Bacterial Core Surveillance, 2008). The following is a graph of U. S. Hib rates in children less than five years old for years 2000-2007. Graph1. U.S. Haemophilus influenzae serotype b Rates in Ages 0-4 Years old for Years 2000-2007 0.23 0.21 0.19 Rates 0.17 0.15 0.13 0.11 0.09 0.07 0.05 Rates 2000 2001 2002 2003 2004 2005 2006 2007 0.20 0.10 0.10 0.20 0.15 0.14 0.22 0.08 Rates of Cases by Years CDC Active Bacterial Core Surveillance Reports for Years 2000-2007 6 The Centers for Disease Control and Prevention Active Bacterial Core Surveillance (ABC) projects the number of cases and fatalities for the U.S. based on their areas of enhanced surveillance. Table 1 below represents past case projections and the case fatality rates. As a comparison, the actual number of cases reported to the Centers for Disease Control and Surveillance is presented in Table 2. It should be noted that the number of reported cases has steadily increased over the years. This increase in reported cases is likely due to the enhanced active surveillance in the project areas. Although the number of reported cases has been increased, it is still assumed that many cases are not being reported and this account for the discrepancy between the reported and the estimated number of cases. Table1. U.S. Projected Number of invasive Haemophilus influenzae Cases and Case Fatality Rates for 2000-2007 # of Cases Rate # of Deaths Case Fatality Rate 2000 3400 2001 3800 2002 3850 2003 3725 2004 4150 2005 4200 2006 4800 2007 4700 Total 32,625 1.2 1.3 1.3 1.3 1.4 1.4 1.6 1.6 1.4 700 625 600 550 725 600 700 700 5200 20.6% 16.4% 15.6% 14.8% 17.5% 14.3% 14.6% 14.9% 15.9% Rates are per 100,000 based on the 2000 U.S. Census Projected Population Provided by the Active Bacterial Core Surveillance (ABC) Table2. Number of U.S. Reported invasive Haemophilus influenzae Cases and Rates for 2000-2007 2000* 2001* 2002* 2003* 2004* 2005* 2006* 2007** Total 1,398 1,597 1,743 2,013 2,085 2,304 2,496 2,541 16,177 # of Cases 0.5 0.6 0 .6 0.7 0 .7 0.8 0.8 0.8 0 .7 Rate Rates are per 100,000 based on the 2000 U.S. Census Projected Population *CDC. Summary of notifiable diseases, United States, 2007 **CDC. Summary of notifiable diseases, United States, 2008 Social Risk Factors Social risk factors for Hib include socioeconomic status, household size, and ethnicity. United States statistics indicate Native Americans and Alaskan Natives are more likely to be diagnosed with a Hib than the rest of the population (CDC, 2008). This increased diagnosis rate is likely due to lower vaccination rates among these groups. Finally, the 7 greatest risk factor is age, with most cases being infected under the age of five years old and a peak age of diagnosis occurring at six to seven months old. Prevention There are two manners in which natural immunity can be acquired. First, immunity is acquired maternally through breastfeeding or the placenta. Second, immunity is thought to occur as a result of natural exposure to the organism. Today, in developed countries, immunity to Hib is more commonly acquired through a series of vaccinations. As historically Hib was the most clinically significant serotype of the bacterium Haemophilus influenzae currently is the only serotype that is vaccine preventable. The following table is the current vaccination schedule for Hib as recommended by the Advisory Committee on Immunization Practices (ACIP) (CDC, 1991). Table3. ACIP-Recommended Haemophilus influenzae type b (Hib) Routine Vaccination Schedule Vaccine PRP-T* PRP-OMP** 2 Months Dose 1 Dose 1 4 Months Dose 2 Dose 2 6 Months Dose 3 12-15 Months Booster Booster * polyribosylribitol phosphate conjugated to tetanus toxoid ** polyribosylribitol phosphate conjugated to an outer-membrane protein of Neisseria meningitidis Chemoprophylaxis Control measures include providing chemoprophylaxis to exposed unimmunized or incompletely immunized household, childcare, or nursery contacts. Haemophilus influenzae Surveillance in Maricopa County for 2000-2007 As directed by Arizona Administrative Code (AAC) R9-6-333 invasive Haemophilus influenzae must be reported within five days after diagnosis and case has been established. A potential case is defined and classified as follows: Clinical Description Invasive disease due to Haemophilus influenzae may produce any of several clinical syndromes including meningitis, bacteriemia, epiglottitis, or pneumonia Laboratory Criteria for Diagnosis Isolation of H. influenzae from a normally sterile site Case Classification Confirmed: A clinically compatible illness that is culture-confirmed Probable: A clinically compatible illness with detection of H. influenzae type b antigen in cerebrospinal fluid. 8 In addition to reporting the case, Arizona Administrative Code mandates that all Haemophilus influenzae isolates be submitted to the Arizona State Public Health Laboratory for serotyping. Case Investigation Methodology A total of 651 Communicable Disease Reports for H. influenzae were received by the Maricopa County Department of Public Health during the years 2000-2007. Three hundred of these reports were ruled out due to one or more of the following reasons: specimen source not being a sterile site, out of jurisdiction, duplicate report received or isolate being of a different Haemophilus species. Five cases were identified through death certificates and eliminated due to an investigation not being completed. The remaining cases included in the analysis consists of those classified as probable (2) and confirmed (344) for a total of 346 meeting the case definition during the years 20002007. Graphs 2 and 3 represent the number and rates of cases reported by years. Graph2. Number of Haemophilus influenzae Cases in Maricopa County by Year of Report for 2000-2007 (N=346) 70 Number of Cases 60 50 40 30 20 10 0 Number of Cases 2000 2001 2002 2003 2004 2005 2006 2007 33 35 46 39 42 59 47 Number of Cases by Year of Report 45 9 Graph3. Maricopa County Haemophilus influenzae Rates by Year of Report for Years 2000-2007 (N=346) 2 1.9 1.8 1.7 Rates 1.6 1.5 1.4 1.3 1.2 1.1 1 Rates 2000 2001 2002 2003 2004 2005 2006 2007 1.1 1.1 1.4 1.1 1.2 1.6 1.2 1.2 Rate by Year of Report Rates are per 100,000 based on U.S. 2000-2007 Census Data for Maricopa County Cases are typically reported by health care providers, with 81% (280) of cases coming from providers. Laboratories reported 19% (66) of cases. Graph 4 summarizes the number of cases received during this time period and the sources of report by year of disease onset. The modes of reporting used by healthcare providers are summarized in Graph 5. The graph indicates that the use of mail to report cases is rapidly declining due to quicker methods such as the use of electronic reporting, telephone, and fax. Graph4. Maricopa County Sources of H. influenzae Reports for Years 2000-2007 (N=346) Number of Reports 60 50 40 30 20 10 0 2000 2001 2002 2003 2004 2005 Year Report Received Provider Reported Lab Unknown 2006 2007 10 Graph5. Modes of Reporting Used by Healthcare Providers for Haemophilus influenzae in Maricopa County for Years 2000-2007 (N=280) Case Investigation Procedure Once a case is received by the Office of Epidemiology, a Community Health Nursing (CHN) staff member will begin investigating the case immediately. The investigation includes confirming the diagnosis, identifying personal contacts, providing chemoprophylaxis if necessary and implementing control measures as needed. The following flowchart is a diagram of the steps implemented to complete an investigation. 11 Diagram 1. Case Investigation Procedures for H. influenzae Case received from laboratory/ health care provider/ Other CHN will contact the Lab to obtain a hard copy of the lab report Positive H. Flu report? No Rule Out No Further Action Taken Yes Contact submitting physician or health care facility to obtain patient information Call Patient for Details Including Possible Onset and Contacts. Provide education Determine if there was close contact with another person with in seven days post onset Yes Determine if Anitibiotics or Vaccination to Hib is Necessary End of Investigation No 12 Epidemiologic Trends in Maricopa County, 2000-2007 The rate of reported infections remained steady between the years 2000-2007. The most cases were reported in the year 2005, and the highest case fatality rates occurred in 2003 and 2005. Of the 346 cases reported during 2000-2007 there were 18 deaths resulting in a case fatality rate of 5.2% (Refer to Table 4). Table4. Number of invasive Haemophilus influenzae Cases and Case Fatality Rates for Years 2000-2007 in Maricopa County 2000 2001 2002 2003 2004 2005 2006 2007 Total 33 35 46 39 42 59 47 45 346 # of Cases 1.1 1.1 1.4 1.1 1.2 1.6 1.2 1.2 1.2 Rate* # of Deaths Case Fatality Rate 0 1 2 5 2 5 3 0 18 0.0% 2.9% 4.3% 12.8% 4.8% 8.5% 6.4% 0.0% 5.2% *Rates are per 100,000 based on 2000-2007 U.S. Census Populations for Maricopa County Seasonality Haemophilus influenzae type b has two peak seasons during the year that were more prominent before the vaccine era began. These peaks reportedly occurred March thru May and September thru December. Graph 6 is a representation of Maricopa County’s cases by month. 13 Graph6. Maricopa County Haemophilus influenzae Cases by Month of Onset for Years 2000-2007 (N=346) Distribution by Serotypes During the years 2000-2007 the H. influenzae organism isolated most often from sterile sites were non-typeable isolates (162 specimens). Serotype c was isolated from 2 specimens making it the serotype that was the least often isolated. Graph 7 shows the contribution each serotype made to the 346 cases. Graph7. Number of Reported Haemophilus influenzae Serotypes for Years 20002007 in Maricopa County (N=346) 14 Two hundred and eighty-nine reported cases were categorized as having bacteremia/sepsis. Meningitis was the second most common syndrome with 44 cases reported. Table 5 illustrates the association between serotypes and diagnosis. Table5. Syndromes by Haemophilus influenzae Serotypes for Years 2000-2007 in Maricopa County Bacteremia/Sepsis Meningitis Pneumonia Unspecified Total A 33 15 0 0 48 B 15 2 0 0 17 C 2 0 0 0 2 D 9 0 0 0 9 E 21 0 2 0 23 F 32 5 3 0 40 Nontypeable 140 19 3 0 162 Unknown 37 3 3 2 45 Total 289 44 11 2 346 Graph 8 is a representation of serotypes by year of report. Each year during the years 2003-2006 the number of non-typeable H. influenzae organisms was greater than all other serotypes combined. Graph8. Haemophilus influenzae Serotype Percentages for Years 2000-2007 in Maricopa County (N=346) Percentage of Cases 100% 80% 60% 40% 20% 0% 2000 2001 2002 2003 2004 2005 2006 2007 Unknow n 8 2 5 6 2 9 8 5 Nontypeable 11 16 19 20 28 28 26 14 F 2 7 7 6 4 7 3 4 E 2 3 0 0 1 9 3 5 D 3 1 3 0 0 0 0 2 C 1 0 0 0 0 0 0 1 B 2 2 2 3 1 1 2 4 A 4 4 10 4 6 5 5 10 Year of Report 15 Case Demographics Cumulatively, 52% of the cases were female, 58% were white, and the age group most represented was 0-4 years old (26%). Serotype b accounted for 5% of the total cases and had an infection rate of 0.18 per 100,000 in those less than five years old. Graph 9 represents the case rates by race/ethnicity and year of report. The graph indicates that the rates for Native Americans are much greater in most years than any other group. Graph9. Rates for Maricopa County Haemophilus influenzae Cases by Race for Years 2000-2007 12.0 10.0 Rates 8.0 6.0 4.0 2.0 0.0 2000 2001 2002 2003 2004 2005 2006 2007 White 0.8 1.2 1.2 1.1 1.4 1.4 1.3 0.9 Hispanic 1.7 0.5 1.4 0.8 0.6 1.7 1.0 1.0 Black 0.9 0.0 3.3 3.2 1.5 1.4 1.3 3.2 Asian/Island Pacif ic 0.0 0.0 0.0 0.0 1.1 1.0 0.9 0.0 Native American 6.3 5.9 9.6 3.8 5.5 6.9 3.3 1.6 Year Reporte d *Rates are Per 100,000 based on 2000-2007 U.S. Census Populations for Maricopa County Graph 10 is a representation of the number of cases by age groups. It indicates that the very young and those sixty-five and older are more likely to be diagnosed with invasive H. influenzae. 16 Graph10. Maricopa County Haemophilus influenzae Cases by Age Groups for Years 2000-2007 (N=346) 100 90 Number of Cases 80 70 60 50 40 30 20 10 0 0- 4 5-9 4 10-1 9 15- 1 4 20-2 4 25- 3 4 35- 4 4 45-5 9 55- 5 4 60-6 4 65- 7 4 75- 8 85+ Age groups Graph 11 presents the rates of reported cases for each age group. The graph demonstrates a steady increase between the ages of 55 and 84 years old but beyond this age there is a steep increase. Graph11. Rates for Haemophilus influenzae Cases in Maricopa County by Age Group for Years 2000-2007 9.0 8.0 7.0 Rate 6.0 5.0 4.0 3.0 2.0 1.0 0.0 Rates 0-4 5-9 4.0 0.8 10-14 15-19 20-24 25-34 35-44 45-54 55-59 60-64 65-74 75-84 0.2 0.2 0.7 0.2 0.3 1.0 1.4 Age Group Rates per 100,000 according to the 2000-2007 U.S. Population Census for Maricopa County 2.1 2.7 4.1 85+ 8.5 17 Graph 12 presents the rates of cases by gender and year of report. The rates demonstrate that in most years females exceed males. The exception is 2001 when the two were equal. Graph12. Maricopa County Haemophilus influenzae Rates by Gender for Years 2000-2007 (N=346) Rates per 100,000 per 2000-2007 U.S. Population Census for Maricopa County Outcome The case fatality rate (CFR) for Haemophilus influenzae during the years 2000-2007 was 5.2%. Individuals who were four years old or less and those who were over the age of 65 were most likely to succumb to the infection representing 22.2% (1.6% CFR) and 50.0% (2.6% CFR) of the fatal cases respectively. Graph 13 is a representative of outcome percentages. 18 Graph13. Maricopa County Haemophilus influenzae Cases by Outcome for Years 2000-2007 (N=346) Unknown 13% Died 5% Survived 82% Haemophilus influenzae isolates classified as non-typeable were more likely to be associated with a fatal case than any other serotype, 44.4%, and had a case fatality rate of 2.3%. Reportedly, none of the cases diagnosed with an invasive disease caused by serotypes c or d resulted in a fatality (Graph 14). Graph14. Maricopa County Haemophilus influenzae Case Fatality Rates by Serotypes for Years 2000-2007 *Expressed as a percentage of total cases 19 Graph 15, represent the association between outcome and age. It should be noted that no deaths were reported for individuals who were within the age range of 5-34 years old during the years 2000-2007. Graph15. Case Fatality Rates for Maricopa County Haemophilus influenzae Cases by Age Groups for Years 2000-2007 (N=346) Graph 16 is a representation of the number of deaths occurring by year the case was reported. In 2003 and 2005, a Haemophilus influenzae infection was associated with five deaths in each year. Graph16. Maricopa County Haemophilus influenzae Cases with a Fatal Outcome by Year Case was Reported and Death Occurred (N=18)* 6 Number of Cases 5 4 3 2 1 0 2000 2001 2002 2003 2004 Year of Report * No deaths were reported for years 2000 and 2007 Vaccinations 2005 2006 2007 20 Twenty-eight cases reported being vaccinated for Haemophilus influenzae serotype b (Hib) either completing the vaccine series (43.0%) or partially completing the series, (57.0%). The most common serotype isolated from these twenty-eight cases was serotype a which made up 43.0% of total cases. According to the data collected during the investigations, whites were more likely to report being vaccinated. Table 6 represents the percentage of children reportedly vaccinated, during the investigation of Haemophilus influenzae cases, by race/ethnicity. Table6. Maricopa County Haemophilus influenzae serotype b vaccinated cases by race for years 2000-2007 Percentage of Race Vaccinated Cases 13 46.0% White 3 11.0% Hispanic 5 18.0% Black 7 25.0% Unknown 28 100.0% Total Haemophilus influenzae serotype b Seventeen cases were diagnosed with Haemophilus influenzae serotype b. Four of the seventeen cases were diagnosed in children under five years old. CDC estimates that the national rate of infection for children under five years old is less than 1 per 100,000 and Maricopa County is similar to that of the rest of U.S with a rate of 0.2 per 100,000. The following graphs (17, 18 and 19) and Table 7 exemplify demographics specific to these cases. Graph17. Maricopa County Haemophilus influenzae serotype b cases by Gender for Years 2000-2007 (N=17) 21 10 9 Number of Cases 8 7 6 5 4 3 2 1 0 Male Female Gender Graph18. Maricopa County Haemophilus influenzae serotype b Cases by Race for Years 2000-2007 (N= 17) Native American 12% Black 12% Hispanic 18% White 58% Table7. Maricopa County Haemophilus influenzae serotype b Cases by Race and Age Rates (per 100,000) 22 Native Age in Years White Hispanic Black American Total* 0-4 .10 (1) .20 (2) 0 (0) 2.26 (1) .18 (4) 5-14 0 .0(0) 0 .0(0) 0.0 (0) 0.0 (0) 0 .0(0) 15-19 0.0 (0) 0.0 (0) 0.0 (0) 0 .0(0) 0.0 (0) 20-34 .03 (1) 0 .0(0) .41 (1) .77 (1) .05 (3) 35-44 0.0 (0) 0.0 (0) 0 .0(0) 0.0 (0) 0.0 (0) 45-54 0.0 (0) 0 .0(0) 0.0 (0) 0.0 (0) 0.0 (0) 55-64 .10 (2) .32 (1) 0.0 (0) 0.0 (0) .12 (3) 65-84 .21 (5) 0 (0) 1.77 (1) 0 (0) .22 (6) 85+ .27 (1) 0 (0) 0 (0) 0 (0) .25 (1) TOTAL** .06 (10) .04 (3) .19 (2) .46 (2) .06 (17)*** *Total population includes all races and ethnicities ie number of cases divided by county population for stated age group multiplied by 100,000 **Specific to cases in stated race/ethnicity ie number of cases within race divided by county population for stated race ***Total population including all races and age groups ie number cases divided by county population (x) Number of cases Graph19. Maricopa County Haemophilus influenzae Type b Cases by Age for Years 2000-2007 (N=17) 8 Number of Cases 7 6 5 4 3 2 1 0 0-4 20-24 55-64 Age in Years 65+ 23 Haemophilus influenzae Data Quality in Maricopa County, 2000-2007 Case data are collected from health care provider and laboratory reports and subsequent county investigations. The quality of disease surveillance is determined by the quality of the collected data. One method for assessing data quality is to measure the number of cases with missing or incomplete data that are present in the database. The following table exemplifies the number of Haemophilus influenzae cases that have missing or incomplete data for selected variables. Table 8 shows that basic patient demographic information is being obtained which enables the county’s community health nurses to begin an investigation. The table also illustrates that the ever important information regarding pregnancy is being obtained 97.7% of the time for females between the ages of 14-55 years old. Finally, the serotype was identified for 87.0% of the cases. Table8. Maricopa County Haemophilus influenzae Data Quality Analysis for Years 2000-2007 Total Total Number Number of % Of of Cases Total Cases with Cases with with % of Cases Number of Field Field Field with Field Cases Complete Complete Missing Missing Field Analyzed Reported Last Name 346 346 100.0% 0 0.0% First Name 346 346 100.0% 0 0.0% Date of Birth 346 346 100.0% 0 0.0% Gender 346 346 100.0% 0 0.0% Male 181 181 100.0% 0 0.0% Female 165 165 100.0% 0 0.0% Complete Patient Address 346 336 97.1% 10 2.9% Outcome (Died/Survived) 346 300 86.7% 46 13.3% Race/Ethnicity 346 338 97.7% 8 2.3% Pregnant (Females between the ages of 14-55 yrs.) 38 35 92.1% 3 7.9% Date of Diagnosis 346 339 98.0% 7 2.0% Date of Onset 346 315 91.0% 31 9.0% Date Report Received 346 346 100.0% 0 0.0% Reporting Source 346 330 95.4% 16 4.6% Serotype 346 301 87.0% 45 13.0% Supplemental Longform Completed 346 303 87.5% 43 12.4% 24 Investigation Timeliness in Maricopa County, 2000-2007 Ideally, infectious disease cases should be reported and the investigation completed before the end of the known incubation period so that further spread of the disease can be avoided. Unfortunately, this is not always possible. Nevertheless, it is still important for the case to be reported and the investigation to occur in a timely manner. The following graph represents the median number of days for each step of the case identification and investigation for the years 2000-2007. Cases for which a definite end or beginning of investigation could not be determined or cases missing other pertinent dates such as onset of disease were omitted from the analysis, 103 (30%) cases. The remaining cases used for this analysis represented 70% (243) of the confirmed cases. Graph20. Median Length of Days from Onset of Disease to Completion of Case Investigation for Maricopa County Haemophilus influenzae Cases for Years 20002007 (N=243) Current and future research Current literature illustrates that although strides have been made in the developed world to effectively decrease Hib there are still unresolved issues. For instance, In the United States the incidence rate has dropped significantly due to the inception of the vaccine (Centers for Disease Control and Prevention, 2008) yet this period of enjoyment could be 25 short-lived due to a genetic adaptation of the organism allowing it become more virulent and causing vaccine failures (Cerquetti et al, 2005). Such issues also include the rise in the number of the unencapsulated, non-typeable, form of the bacteria isolated from sterile sites. In a study researchers, using data from several states, determined that non-typeable serotypes were more commonly isolated from sterile sites than any other serotype (Dworkin, Park, & Borchardt, 2007). Although Maricopa County’s data was not apart of this study the results are consistent with data presented in previous sections of this summary. Future studies should determine if the unencapsulated organism has adapted to be more virulent or was its magnitude overlooked in the beginning. An intriguing question for future consideration is now that H. influenzae serotype b is somewhat contained in the United States will it become necessary to increase surveillance and create a vaccine for the emerging unencapsulated form of H. influenzae. As the data for Maricopa County and past studies have shown African Americans and Native Americans/Alaskan Natives are disproportionately affected by H. influenzae primarily type b. Two thoughts abound as to the cause one is that African Americans and Native Americans/Alaskan Natives are genetically more susceptible and the other is that both groups are typically in lower socioeconomic strata causing them to reside in close confined areas (Rust & Cavaliere, 2006). Studies have yet proved, sufficiently, either thought therefore more research is needed in this area to find the cause. Conclusions 1. The rate of children less than five years old diagnosed in Maricopa County between the years 2000-2007 with Haemophilus influenzae type b was less than the US national rate for the same age group and time period. In fact, Maricopa County’s rate is close to the U.S. Healthy People 2010 goal. 2. The majority of Haemophilus infections presented as bacteremia/sepsis 3. The majority of infections that are caused by Haemophilus influenzae were nontypeable, these organisms were responsible for more deaths than any other serotype. 4. Individuals most commonly infected with Haemophilus influenzae, all serotypes and non-typeable, were over the age of sixty-five and those less than five years old. Future actions should include: • Increasing the quantity and quality of investigations by the Maricopa County Health Department 26 • Encouraging clinical laboratories to send more isolates to the Arizona State Public Health Laboratory for serotyping thereby decreasing the number of unknown serotype • Investigating the rising number of non-typeable isolates • Investigating the causes for the disproportionate number of cases among African Americans and Native Americans 27 Appendix 28 A. Seasonality A. Table 1-Haemophilus influenzae by Month for Years 2000-2007 2000 2001 2002 2003 2004 2005 2006 January 4 4 3 6 4 6 3 February 3 5 6 8 13 12 7 March 6 3 7 5 4 8 4 April 4 1 4 3 2 5 4 May 1 1 4 4 4 6 4 June 1 0 0 3 1 2 7 July 3 0 2 1 4 1 3 August 1 3 3 0 3 2 4 September 0 1 2 2 1 4 0 October 3 4 6 2 1 5 1 November 1 5 6 3 1 1 2 December 6 8 3 2 4 7 8 Total 33 35 46 39 42 59 47 2007 10 3 5 5 4 3 2 1 1 3 4 4 45 Total 40 57 42 28 28 17 16 17 11 25 23 42 346 B. Cases and Deaths of Invasive Haemophilus influenzae by Serotype B. Table 1-Cases and Death of Haemophilus influenzae by Serotype in 2000 Cases Deaths # % Rate # % Serotype Case Fatality Rate (%) A 4 12.1 .13 0 0 0.0% B 2 6.1 .07 0 0 0.0% C 1 3.0 .03 0 0 0.0% D 3 9.1 .10 0 0 0.0% E 2 6.1 .07 0 0 0.0% F 2 6.1 .07 0 0 0.0% Non11 33.3 .36 0 0 0.0% typeable Unknown 8 24.2 .26 0 0 0.0% Total 33 100.0% 1.1 0 0.0% 0.0% 29 B. Table 2-Cases and Death of Haemophilus influenzae by Serotype in 2001 Cases Deaths # % Rate # % Serotype Case Fatality Rate (%) A 4 11.4 .12 0 0.0 0.0% B 2 5.7 .06 0 0.0 0.0% C 0 0.0 0.0 0 0.0 0.0% D 1 2.9 .03 0 0.0 0.0% E 3 8.6 .09 0 0.0 0.0% F 7 20.0 .22 0 0.0 0.0% Non16 45.7 .50 0 0.0 0.0% typeable Unknown 2 5.7 .06 1 100.0 2.7% Total 35 100.0% 1.1 1 100.0% 2.7% B. Table 3-Cases and Death of Haemophilus influenzae by Serotype in 2002 Deaths Cases # % Rate # % Serotype Case Fatality Rate A 10 21.7 .30 1 50.0 2.2% B 2 4.4 .06 0 0.0 0.0% C 0 0.0 0 0 0.0 0.0% D 3 6.5 .09 0 0.0 0.0% E 0 0.0 0 0 0.0 0.0% F 7 15.2 .21 0 0.0 0.0% Non19 41.3 .58 1 50.0 2.2% typeable Unknown 5 10.9 .15 0 0.0 0.0% Total 46 100.0% 1.4 2 100.0% 4.4% 30 B. Table 4-Cases and Death of Haemophilus influenzae by Serotype in 2003 Cases Deaths % Rate # % Serotype # Case Fatality Rate A 4 10.3 .12 0 0.0 0.0% B 3 7.7 .08 1 20.0 2.56% C 0 0.0 0 0 0.0 0.00% D 0 0.0 0 0 0.0 0.00% E 0 0.0 0 0 0.0 0.00% F 6 15.4 .18 2 40.0 5.13% Non20 51.3 .59 1 20.0 2.56% typeable Unknown 6 15.4 .18 1 20.0 2.56% 39 100.0% 1.1 5 100.0% 12.82% Total B. Table 5-Cases and Death of Haemophilus influenzae by Serotype in 2004 Cases Deaths Serotype # % Rate # % Case Fatality Rate A 6 14.3 .17 0 0.0 0.0% B 1 2.4 .03 0 0.0 0.0% C 0 0.0 0 0 0.0 0.0% D 0 0.0 0 0 0.0 0.0% E 1 2.4 .03 0 0.0 0.0% F 4 9.5 .11 0 0.0 0.0% Non-typeable 28 66.7 .80 1 50.0 2.4% Unknown 2 4.8 .06 1 50.0 2.4% Total 42 100.0% 1.2 2 100.0% 4.8% 31 B. Table 6-Cases and Death of Haemophilus influenzae by Serotype in 2005 Cases Deaths # % Rate # % Serotype Case Fatality Rate A 5 8.5 .14 1 20.0 1.69% B 1 1.7 .03 0 0.0 0.0% C 0 0.0 0 0 0.0 0.0% D 0 0.0 0 0 0.0 0.0% E 9 15.3 .25 1 20.0 1.69% F 7 11.9 .19 1 20.0 1.69% Non28 47.5 .77 2 40.0 3.39% typeable Unknown 9 15.3 .25 0 0.0 0.0% Total 59 100.0% 1.6 5 100.0% 8.47% B. Table 7-Cases and Death of Haemophilus influenzae by Serotype in 2006 Cases Deaths # % Rate # % Serotype Case Fatality Rate A 5 10.6 .13 0 0.0 0.0% B 2 4.3 .05 0 0.0 0.0% C 0 0.0 0.0 0 0.0 0.0% D 0 0.0 0.0 0 0.0 0.0% E 3 6.4 .08 0 0.0 0.0% F 3 6.4 .08 0 0.0 0.0% Non26 55.3 .69 3 100.0 6.4% typeable Unknown 8 17.0 .21 0 0.0 0.0% Total 47 100.0% 1.24 3 100.0% 6.4% 32 B. Table 8-Cases and Death of Haemophilus influenzae by Serotype in 2007 Cases Deaths # % Rate # % Serotype Case Fatality Rate 10 A 22.2 .26 0 0.0 0.0% 4 B 8.9 .10 0 0.0 0.0% 1 C 2.2 .03 0 0.0 0.0% 2 D 4.4 .05 0 0.0 0.0% 5 E 11.1 .13 0 0.0 0.0% 4 F 8.9 .10 0 0.0 0.0% 14 Non31.1 .36 0 0.0 0.0% typeable 5 Unknown 11.1 .13 0 0.0 0.0% 45 100.00% Total 1.2 0 0.0% 0.0% B. Table 9-Cases and Death by Haemophilus influenzae by Serotype for 2000-2007 Cases Deaths % Rate # % Case Fatality Rate Serotype # A 48 13.9 .17 2 11.1 .58% B 17 4.9 .06 1 5.6 .29% C 2 .6 .01 0 0.0 0.0% D 9 2.6 .03 0 0.0 0.0% E 23 6.7 .08 1 5.6 .29% F 40 11.6 .14 3 16.7 .87% Non162 46.8 .58 8 44.4 2.31% typeable Unknown 45 13.0 .18 3 16.7 .87% Total 346 100.0% 1.3 18 100.0% 5.20% 33 C. Cases & Deaths of Haemophilus influenzae by Race/Ethnicity for Years 20002007 C. Table 1-Cases & Deaths of Haemophilus influenzae by Race/Ethnicity in 2000 Cases Deaths # % Rate* # % Race Case Fatality Rate** White 16 48.5 .78 0 0.0 0.0% Hispanic 13 39.4 1.70 0 0.0 0.0% Black 1 3.0 .91 0 0.0 0.0% Asian/Pacific 0 0.0 0.0 0 0.0 0.0% Islander Native 3 9.1 6.30 0 0.0 0.0% American/Alaskan Native Other 0 0.0 0 0.0 0.0% Unknown 0 0.0 0 0.0 0.0% Total 33 100.0% 1.07 0 0.0% 0.0% *Individual race rates were calculated using race specific population; the total rate is based on the total population. **Case Fatality Rates calculated using total number of cases. C. Table 2-Cases & Deaths of Haemophilus influenzae by Race/Ethnicity in 2001 Cases Deaths # % Rate* # % Race Case Fatality Rate** White 26 74.3 1.24 1 100.0 2.9% Hispanic 4 11.4 .48 0 0.0 0.0% Black 0 0.0 0.0 0 0.0 0.0% Asian/Pacific 0 0.0 0.0 0 0.0 0.0% Islander Native 3 8.6 5.91 0 0.0 0.0% American/Alaskan Native Other 0 0.0 0 0.0 0.0% Unknown 2 5.7 0 0.0 0.0% Total 35 100.0% 1.09 1 100.0% 2.9% *Individual race rates were calculated using race specific population; the total rate is based on the total population. **Case Fatality Rates calculated using total number of cases. 34 C. Table 3-Cases & Deaths of Haemophilus influenzae by Race/Ethnicity in 2002 Cases Deaths # % Rate* # % Race Case Fatality Rate** White 25 54.4 1.18 1 50.0 2.2% Hispanic 12 26.1 1.36 1 50.0 2.2% Black 4 8.7 3.30 0 0.0 0.0% Asian/Pacific 0 0.00 0 0 0.0 0.0% Islander Native 5 10.9 9.62 0 0.0 0.0% American/Alaskan Native Other 0 0.0 0 0.0 0.0% Unknown 0 0.0 0 0.0 0.0% Total 46 100.0% 1.39 2 100.0% 4.4% *Individual race rates were calculated using race specific population; the total rate is based on the total population. **Case Fatality Rates calculated using total number of cases. C. Table 4-Cases & Deaths of Haemophilus influenzae by Race/Ethnicity in 2003 Cases Deaths # % Rate* # % Race Case Fatality Rate** White 24 61.5 1.11 2 40.0 5.13% Hispanic 7 18.0 .75 1 20.0 2.56% Black 4 10.3 3.18 0 0.0 0.0% Asian/Pacific 0 0.00 0 0 0.0 0.0% Islander Native 2 5.1 3.76 1 20.0 2.56% American/Alaskan Native Other 1 2.6 0 0.0 0.0% Unknown 1 2.6 1 20.0 2.56% Total 39 100.0% 1.15 5 100.0% 12.82% *Individual race rates were calculated using race specific population; the total rate is based on the total population. **Case Fatality Rates calculated using total number of cases. 35 C. Table 5-Cases & Deaths of Haemophilus influenzae by Race/Ethnicity in 2004 Cases Deaths # % Rate* # % Race Case Fatality Rate** White 30 71.4 1.37 2 100.0 4.8% Hispanic 6 14.3 .61 0 0.0 0.0% Black 2 4.8 1.51 0 0.0 0.0% Asian/Pacific 1 2.4 1.10 0 0.0 0.0% Islander Native 3 7.1 5.46 0 0.0 0.0% American/Alaskan Native Other 0 0.0 0 0.0 0.0% Unknown 0 0.0 0 0.0 0.0% Total 42 100.0% 1.20 2 100.0% 4.8% *Individual race rates were calculated using race specific population; the total rate is based on the total population. **Case Fatality Rates calculated using total number of cases. C. Table 6-Cases & Deaths of Haemophilus influenzae by Race/Ethnicity in 2005 Cases Deaths # % Rate* # % Race Case Fatality Rate** White 31 52.5 1.38 0 0.0 0.0% Hispanic 18 30.5 1.71 2 40.0 3.39% Black 2 3.4 1.42 0 0.0 0.0% Asian/Pacific 1 1.7 1.01 1 20.0 1.69% Islander Native 4 6.8 6.92 1 20.0 1.69% American/Alaskan Native Other 1 1.7 0 0.0 0.0% Unknown 2 3.4 1 20.0 1.69% Total 59 100.0% 1.62 5 100.0% 8.47% *Individual race rates were calculated using race specific population; the total rate is based on the total population. **Case Fatality Rates calculated using total number of cases. 36 C. Table7-Cases & Deaths of Haemophilus influenzae by Race/Ethnicity in 2006 Cases Deaths # % Rate* # % Race Case Fatality Rate** White 30 63.8 1.31 2 66.7 4.3% Hispanic 11 23.4 .98 0 0.0 0.0% Black 2 4.3 1.33 0 0.0 0.0% Asian/Pacific 1 2.1 .93 1 33.3 2.1% Islander Native 2 4.3 3.32 0 0.0 0.0% American/Alaskan Native Other 1 2.1 0 0.0 0.0% Unknown 0 0.0 0 0.0 0.0% Total 47 100.0% 1.24 3 100.0% 6.4% *Individual race rates were calculated using race specific population; the total rate is based on the total population. **Case Fatality Rates calculated using total number of cases. C. Table 8-Cases & Deaths of Haemophilus influenzae by Race/Ethnicity in 2007 Cases Deaths # % Rate* # % Race Case Fatality Rate** 21 White 46.7 .91 0 0.0 0.0% 12 Hispanic 26.7 1.01 0 0.0 0.0% 5 Black 11.1 3.15 0 0.0 0.0% 0 Asian/Pacific 0.0 0 0 0.0 0.0% Islander 1 Native 2.2 1.62 0 0.0 0.0% American/Alaskan Native 3 Other 6.7 0 0.0 0.0% 3 Unknown 6.7 0 0.0 0.0% 45 100.0% Total 1.16 0 0.0% 0.0% *Individual race rates were calculated using race specific population; the total rate is based on the total population. **Case Fatality Rates calculated using total number of cases. 37 C. Table 9-Cases & Deaths of Haemophilus influenzae by Race/Ethnicity in 20002007 Cases Deaths # % Rate* # % Race Case Fatality Rate** White 203 58.7 1.16 8 44.4 2.31% Hispanic 83 24.0 1.07 4 22.2 1.16% Black 20 5.8 1.89 0 0.0 0.0% Asian/Pacific 3 .9 .41 2 11.1 .58% Islander Native 23 6.7 5.25 2 11.1 .58% American/Alaskan Native Other 6 1.7 0 0.00 0.0% Unknown 8 2.3 2 11.1 .58% Total 346 100.0% 1.25 18 100.0% 5.20% *Individual race rates were calculated using race specific population; the total rate is based on the total population. **Case Fatality Rates calculated using total number of cases. D. Cases & Deaths of Haemophilus influenzae in MC by Gender in 2000-2007 D. Table 1-Cases & Deaths of Haemophilus influenzae in MC by Gender in 2000 Cases Deaths # % Rate* # % Gender Case Fatality Rate** Female 18 54.6 1.17 0 0.0 0.0% Male 15 45.5 .98 0 0.0 0.0% Total 33 100.0% 1.07 0 0.0% 0.0% *Individual gender rates were calculated using gender subpopulation; the total rate is based on the total population. **Case Fatality Rates calculated using total number of cases. D. Table 2-Cases & Deaths of Haemophilus influenzae in MC by Gender in 2001 Cases Deaths # % Rate* # % Gender Case Fatality Rate** Female 17 48.6 1.06 1 100.0 2.9% Male 18 51.4 1.12 0 0.0 0.0% Total 35 100.0% 1.09 1 100.0% 2.9% *Individual gender rates were calculated using gender subpopulation; the total rate is based on the total population. **Case Fatality Rates calculated using total number of cases. 38 D. Table 3-Cases & Deaths of Haemophilus influenzae in MC by Gender in 2002 Cases Deaths % Rate* % Gender # # Case Fatality Rate** Female 25 54.4 1.52 1 50.0 2.2% Male 21 45.7 1.27 1 50.0 2.2% Total 46 100.0% 1.39 2 100.0% 4.4% *Individual gender rates were calculated using gender subpopulation; the total rate is based on the total population. **Case Fatality Rates calculated using total number of cases. D. Table 4-Cases & Deaths of Haemophilus influenzae in MC by Gender in 2003 Cases Deaths # % Rate* # % Gender Case Fatality Rate** Female 22 56.4 1.30 3 60.0 7.69% Male 17 43.6 1.00 2 40.0 5.13% Total 39 100.0% 1.14 5 100.0% 12.82% *Individual gender rates were calculated using gender subpopulation; the total rate is based on the total population. **Case Fatality Rates calculated using total number of cases. D. Table 5-Cases & Deaths of Haemophilus influenzae in MC by Gender in 2004 Cases Deaths # % Rate* # % Gender Case Fatality Rate** Female 24 57.1 1.38 2 50.0 4.8% Male 18 42.9 1.02 0 0.0 0.0% Total 42 100.0% 1.20 2 100.0% 4.8% *Individual gender rates were calculated using gender subpopulation; the total rate is based on the total population. **Case Fatality Rates calculated using total number of cases. D. Table 6-Cases & Deaths of Haemophilus influenzae in MC by Gender in 2005 Cases Deaths Gender # % Rate* # % Case Fatality Rate** Female 31 52.5 1.71 3 60.0 5.08% Male 28 47.5 1.53 2 40.0 3.39% Total 59 100.0 1.62 5 100.0 8.47% *Individual gender rates were calculated using gender subpopulation; the total rate is based on the total population. **Case Fatality Rates calculated using total number of cases. 39 D. Table7-Cases & Deaths of Haemophilus influenzae in MC by Gender in 2006 Cases Deaths % Rate* Gender # # % Case Fatality Rate** Female 23 48.9 1.23 1 33.3 2.1% Male 24 51.1 1.26 2 66.7 4.3% Total 47 100.0% 1.24 3 100.0% 6.4% *Individual gender rates were calculated using gender subpopulation; the total rate is based on the total population. **Case Fatality Rates calculated using total number of cases. D. Table 8-Cases & Deaths of Haemophilus influenzae in MC by Gender in 2007 Cases Deaths # % Rate* # % Gender Case Fatality Rate** Female 21 46.7 1.09 0 0.0 0.0% Male 24 53.3 1.23 0 0.0 0.0% Total 45 100.0% 1.16 0 0.0% 0.0% *Individual gender rates were calculated using gender subpopulation; the total rate is based on the total population. **Case Fatality Rates calculated using total number of cases. D. Table 9-Case & Deaths of Haemophilus influenzae in MC by Gender in 20002007 Cases Deaths # % Rate* # % Gender Case Fatality Rate** Female 181 52.3 1.31 11 61.1 3.18% Male 165 47.7 1.18 7 38.9 2.02% Total 346 100.0% 1.25 18 100.0% 5.20% *Individual gender rates were calculated using gender subpopulation; the total rate is based on the total population. **Case Fatality Rates calculated using total number of cases. 40 E. Cases & Deaths of Haemophilus influenzae in MC by Agegroup in 2000-2007 E. Table 1-Cases & Deaths of Haemophilus influenzae in MC by Agegroup in 2000 Cases Deaths # % Rate* # % Age Case Fatality Rate** (in years) 0-4 13 39.4 5.37 0 0.0 0.0% 5-9 3 9.1 1.26 0 0.0 0.0% 10-14 0 0.0 0 0 0.0 0.0% 15-19 1 3.0 .47 0 0.0 0.0% 20-24 1 3.0 .45 0 0.0 0.0% 25-34 0 0.0 0 0 0.0 0.0% 35-44 0 0.0 0 0 0.0 0.0% 45-54 1 3.0 .27 0 0.0 0.0% 55-59 1 3.0 .75 0 0.0 0.0% 60-64 2 6.1 1.86 0 0.0 0.0% 65-74 5 15.2 2.65 0 0.0 0.0% 75-84 4 12.1 3.08 0 0.0 0.0% 85+ 2 6.1 4.98 0 0.0 0.0% Total 33 100.0% 1.07 0 0.0% 0.0% *Individual agegroup rates were calculated using agegroup subpopulation; the total rate is based on the total population. **Case Fatality Rates calculated using total number of cases. E. Table 2-Cases & Deaths of Haemophilus influenzae in MC by Agegroup in 2001 Cases Deaths # % Rate* # % Age Case Fatality Rate** (in years) 0-4 7 20.0 2.7 0 0.0 0.0% 5-9 0 0.0 0 0 0.0 0.0% 10-14 1 2.9 .43 0 0.0 0.0% 15-19 0 0.0 0 0 0.0 0.0% 20-24 1 2.9 .42 0 0.0 0.0% 25-34 0 0.0 0 0 0.0 0.0% 35-44 1 2.9 .20 0 0.0 0.0% 45-54 7 20.0 1.79 0 0.0 0.0% 55-59 2 5.7 1.40 0 0.0 0.0% 60-64 4 11.4 3.52 1 100.0 2.9% 65-74 4 11.4 2.11 0 0.0 0.0% 75-84 4 11.4 2.98 0 0.0 0.0% 85+ 4 11.4 9.27 0 0.0 0.0% Total 35 100.0% 1.09 1 100.0% 2.9% *Individual agegroup rates were calculated using agegroup subpopulation; the total rate is based on the total population. **Case Fatality Rates calculated using total number of cases. 41 E. Table 3-Cases & Deaths of Haemophilus influenzae in MC by Agegroup in 2002 Cases Deaths # % Rate* # % Age Case Fatality Rate** (in years) 0-4 16 34.8 6.03 1 50.0 2.2% 5-9 2 4.4 .79 0 0.0 0.0% 10-14 1 2.2 .41 0 0.0 0.0% 15-19 0 0.0 0 0 0.0 0.0% 20-24 2 4.4 .81 0 0.0 0.0% 25-34 3 6.7 .58 0 0.0 0.0% 35-44 1 2.2 .20 0 0.0 0.0% 45-54 3 6.5 .74 0 0.0 0.0% 55-59 1 2.2 .64 0 0.0 0.0% 60-64 4 8.7 3.3 0 0.0 0.0% 65-74 7 15.2 3.7 1 50.0 2.2% 75-84 2 4.4 1.5 0 0.0 0.0% 85+ 4 8.7 9 0 0.0 0.0% Total 46 100.0% 1.4 2 100.0% 4.4% *Individual agegroup rates were calculated using agegroup subpopulation; the total rate is based on the total population. **Case Fatality Rates calculated using total number of cases. E. Table 4-Cases & Deaths of Haemophilus influenzae in MC by Agegroup in 2003 Cases Deaths # % Rate* # % Age Case Fatality Rate** (in years) 0-4 5 12.8 1.89 0 0.0 0.0% 5-9 2 5.1 .80 0 0.0 0.0% 10-14 0 0.0 0 0 0.0 0.0% 15-19 0 0.0 0 0 0.0 0.0% 20-24 4 10.3 1.62 0 0.0 0.0% 25-34 1 2.6 .19 0 0.0 0.0% 35-44 1 2.6 .19 0 0.0 0.0% 45-54 5 12.8 1.19 1 20.0 2.56% 55-59 3 7.7 1.80 0 0.0 0.0% 60-64 3 7.7 2.31 0 0.0 0.0% 65-74 4 10.3 2.06 1 20.0 2.56% 75-84 4 10.3 2.87 0 0.0 0.0% 85+ 7 18.0 14.53 3 60.0 7.69% Total 39 100.0% 1.15 5 100.0% 12.82% *Individual agegroup rates were calculated using agegroup subpopulation; the total rate is based on the total population. **Case Fatality Rates calculated using total number of cases. 42 E. Table 5-Cases & Deaths of Haemophilus influenzae in MC by Agegroup in 2004 Cases Deaths # % Rate* # % Age Case Fatality Rate** (in years) 0-4 10 23.8 3.47 0 0.0 0.0% 5-9 2 4.8 .76 0 0.0 0.0% 10-14 1 2.4 .39 0 0.0 0.0% 15-19 1 2.4 .43 0 0.0 0.0% 20-24 2 4.8 .80 0 0.0 0.0% 25-34 0 0.0 0 0 0.0 0.0% 35-44 3 7.1 .58 0 0.0 0.0% 45-54 5 11.9 1.14 1 50.0 2.4% 55-59 2 4.8 1.12 0 0.0 0.0% 60-64 2 4.8 1.44 0 0.0 0.0% 65-74 5 11.9 2.52 1 50.0 2.4% 75-84 6 14.3 4.23 0 0.0 0.0% 85+ 3 7.1 5.91 0 0.0 0.0% Total 42 100.0% 1.20 2 100.0% 4.8% *Individual agegroup rates were calculated using agegroup subpopulation; the total rate is based on the total population. **Case Fatality Rates calculated using total number of cases. E. Table 6-Cases & Deaths of Haemophilus influenzae in MC by Agegroup in 2005 Cases Deaths # % Rate* # % Case Fatality Rate** Age (in years) 0-4 14 23.7 4.60 2 40.0 3.39% 5-9 1 1.7 .37 0 0.0 0.0% 10-14 0 0.0 0 0 0.0 0.0% 15-19 1 1.7 .41 0 0.0 0.0% 20-24 1 1.7 .40 0 0.0 0.0% 25-34 2 3.4 .35 0 0.0 0.0% 35-44 3 5.1 .56 0 0.0 0.0% 45-54 6 10.2 1.30 1 20.0 1.69% 55-59 4 6.8 2.08 0 0.0 0.0% 60-64 3 5.1 2.02 0 0.0 0.0% 65-74 5 8.5 2.45 0 0.0 0.0% 75-84 13 22.0 8.96 2 40.0 3.39% 85+ 6 10.2 11.07 0 0.0 0.0% Total 59 100.0% 1.62 5 100.0% 8.47% *Individual agegroup rates were calculated using agegroup subpopulation; the total rate is based on the total population. **Case Fatality Rates calculated using total number of cases. 43 E. Table 7-Cases & Deaths of Haemophilus influenzae in MC by Agegroup in 2006 Cases Deaths # % Rate* # % Age Case Fatality Rate** (in years) 0-4 15 31.9 4.77 1 33.3 2.1% 5-9 3 6.4 1.05 0 0.0 0.0% 10-14 0 0.0 0 0 0.0 0.0% 15-19 1 2.1 .40 0 0.0 0.0% 20-24 2 4.3 .80 0 0.0 0.0% 25-34 0 0.0 0 0 0.0 0.0% 35-44 1 2.1 .18 0 0.0 0.0% 45-54 5 10.6 1.03 0 0.0 0.0% 55-59 3 6.4 1.46 1 33.3 2.1% 60-64 1 2.1 .64 0 0.0 0.0% 65-74 7 14.9 3.30 1 33.3 2.1% 75-84 5 10.6 3.40 0 0.0 0.0% 85+ 4 8.5 6.89 0 0.0 0.0% Total 47 100.0% 1.24 3 100.0% 6.3% *Individual agegroup rates were calculated using agegroup subpopulation; the total rate is based on the total population. **Case Fatality Rates calculated using total number of cases. E. Table 8-Cases & Deaths of Haemophilus influenzae in MC by Agegroup in 2007 Cases Deaths # % Rate* # % Age Case Fatality Rate** (in years) 0-4 11 24.4 3.40 0 0.0 0.0% 5-9 4 8.9 1.36 0 0.0 0.0% 10-14 0 0.0 0 0 0.0 0.0% 15-19 0 0.0 0 0 0.0 0.0% 20-24 1 2.2 .40 0 0.0 0.0% 25-34 1 2.2 .17 0 0.0 0.0% 35-44 4 8.9 .71 0 0.0 0.0% 45-54 2 4.4 .40 0 0.0 0.0% 55-59 3 6.7 1.44 0 0.0 0.0% 60-64 4 8.9 2.35 0 0.0 0.0% 65-74 6 13.3 2.70 0 0.0 0.0% 75-84 5 11.1 3.37 0 0.0 0.0% 85+ 4 8.9 6.48 0 0.0 0.0% Total 45 100.0% 1.03 0 0.0% 0.0% *Individual agegroup rates were calculated using agegroup subpopulation; the total rate is based on the total population. **Case Fatality Rates calculated using total number of cases. 44 E. Table 9-Cases & Deaths of Haemophilus influenzae in MC by Agegroup in 20002007 Cases Deaths # % Rate* # % Age Case Fatality Rate** (in years) 0-4 91 26.3 4.01 4 22.2 1.16% 5-9 17 4.9 .81 0 0.0 0.0% 10-14 3 .9 .15 0 0.0 0.0% 15-19 4 1.2 .21 0 0.0 0.0% 20-24 14 4.1 .72 0 0.0 0.0% 25-34 7 2.0 .16 0 0.0 0.0% 35-44 14 4.1 .34 0 0.0 0.0% 45-54 34 9.8 .98 3 16.7 .87% 55-59 19 5.5 1.37 1 5.6 .29% 60-64 23 6.7 2.11 1 5.6 .29% 65-74 43 12.4 2.69 4 22.2 1.16% 75-84 43 12.4 4.10 2 11.1 .58% 85+ 34 9.8 8.47 3 16.7 .87% Total 346 100.0% 1.25 18 100.0% 5.20% *Individual agegroup rates were calculated using agegroup subpopulation; the total rate is based on the total population. **Case Fatality Rates calculated using total number of cases. F. Population Estimates for Maricopa County, 2000-2007 Year 2000 2001 2002 2003 2004 2005 2006 2007 20002007 F. Table 1-MC Population for years 2000-2007, by Race/Ethnicity per U.S. Census Bureau Race/Ethnicity White Hispanic Black Native Asian/Island Other Total Am./Alaskan Pacific Native 2,046,444 763,341 110,195 47,60 69,928 34,634 3,072,149 2,091,450 829,443 115,913 50,730 76,137 37,171 3,200,844 2,124,085 882,774 121,056 51,961 81,286 39,263 3,300,425 2,154,117 932,070 125,760 53,190 85,813 41,566 3,392,516 2,195,688 985,790 132,286 54,938 91,200 44,241 3,504,143 2,248,480 1,052,764 141,055 57,820 98,886 47,564 3,646,569 2,286,987 1,121,985 150,801 60,185 107,778 50,862 3,778,598 2,309,547 1,182,656 158,688 61,605 114,246 53,439 3,880,181 17,456,798 7,750,823 1,055,754 438,036 725,274 348,740 27,775,425 45 F. Table 2-MC Population for Years 2000-2007, by Gender per U.S. Census Bureau Gender Year Female 2000 2001 2002 2003 2004 2005 2006 2007 1,535,676 1,597,427 1,645,438 1,690,266 1,743,562 1,813,086 1,876,914 1,926,105 Male 1,536,473 1,603,417 1,654,987 1,702,250 1,760,581 1,833,483 1,901,684 1,954,076 Total 3,072,149 3,200,844 3,300,425 3,392,516 3,504,143 3,646,569 3,778,598 3,880,181 F. Table 3- MC Population for Years 2000-2007, by Gender per U.S. Census Bureau Gender Years 2000-2007 Female Male Total Age (In years) 0-4 5-9 10-14 15-19 20-24 25-34 35-44 45-54 55-59 60-64 65-74 75-84 85+ Total 13,828,474 13,946,951 27,775,425 F. Table 4-MC Population for years 2000-2007 by Age Per U.S. Census Bureau Year 2000 2001 2002 2003 2004 2005 2006 241,974 238,222 222,056 214,672 224,444 488,329 475,907 366,464 133,812 107,290 188,816 130,036 40,127 3,072,149 255,183 245,505 234,051 216,789 239,588 504,371 490,375 391,744 142,527 113,743 189,548 134,289 43,131 3,200,844 265,178 251,549 242,454 219,526 246,882 519,991 499,483 405,171 156,534 120,573 191,064 136,853 45,167 3,300,425 276,474 255,739 250,143 224,296 249,012 532,429 506,601 420,438 166,442 129,762 193,823 139,200 48,157 3,392,516 288,381 262,619 257,625 231,816 249,274 549,726 518,979 437,632 178,257 139,015 198,373 141,770 50,676 3,504,143 304,037 272,035 266,011 242,268 249,676 569,515 537,454 461,087 192,169 148,792 204,272 145,039 54,214 3,646,569 314,742 285,086 273,966 251,957 249,235 585,795 555,797 481,996 205,878 157,040 212,154 146,867 58,085 3,778,598 2007 323,861 294,409 279,646 260,467 248,418 595,579 564,758 501,230 208,977 170,461 222,478 148,197 61,700 3,880,181 46 F. Table 5-MC Population for years 2000-2007 by Age Per U.S. Census Bureau Age ( in Years) Years 2000-2007 0-4 2,269,830 5-9 2,105,164 10-14 2,025,952 15-19 1,861,791 20-24 1,956,529 25-34 4,345,735 35-44 4,149,354 45-54 3,465,762 55-59 1,384,596 60-64 1,086,676 65-74 1,600,528 75-84 1,122,251 85+ 401,257 Total 27,775,425 47 F. Table 6-MC Population, 2000, by Age and Race Per U.S. Census Bureau White Hispanic Black 0-4 119,413 97,104 9,544 5-9 125,584 87,461 10,546 10-14 126,795 71,987 10,354 15-19 121,915 71,357 9,224 20-24 119,951 82,685 8,267 25-29 140,908 81,013 8,991 30-34 150,278 68,174 9,282 35-39 168,355 56,866 9,786 40-44 165,771 42,846 9,000 45-49 147,542 31,450 7,033 50-54 136,761 23,287 5,213 55-59 110,035 15,646 3,658 60-64 89,910 10,957 2,900 65-69 84,156 8,325 2,214 70-74 81,783 6,227 1,664 75-79 71,992 4,040 1,145 80-84 48,071 2,217 725 85+ 37,224 1,699 649 TOTAL 2,046,444 763,341 110,195 Native Asian/Pacific American Islander Other Total 4,558 5,047 6,308 241,974 4,730 4,751 5,150 238,222 4,469 4,393 4,058 222,056 4,417 4,443 3,316 214,672 5,259 5,558 2,724 224,444 5,053 8,274 2,454 246,693 4,358 7,510 2,034 241,636 3,963 6,723 1,973 247,666 3,166 5,796 1,662 228,241 2,355 4,799 1,325 194,504 1,848 3,819 1,032 171,960 1,139 2,588 746 133,812 857 2,086 580 107,290 521 1,626 434 97,276 359 1,171 336 91,540 279 682 234 78,372 143 376 132 51,664 133 286 136 40,127 47,607 69,928 34,634 3,072,149 48 F. Table 7-MC Population, 2001, by Age and Race Per U.S. Census Bureau Asian/Pacific Native White Hispanic Black Other Total American Islander 0-4 121,627 105,728 10,352 4,916 5,671 6,889 255,183 5-9 124,878 94,043 10,735 4,822 5,197 5,830 245,505 10-14 129,921 78,998 10,910 4,887 4,804 4,531 234,051 15-19 122,849 71,500 9,747 4,477 4,647 3,569 216,789 20-24 126,994 89,431 8,817 5,756 5,588 3,002 239,588 25-29 134,819 89,155 9,197 5,225 8,664 2,465 249,525 30-34 154,435 75,460 9,535 4,740 8,509 2,167 254,846 35-39 165,105 62,274 10,058 4,138 7,206 1,940 250,721 40-44 170,940 47,751 9,524 3,466 6,284 1,689 239,654 45-49 153,681 34,956 7,453 2,473 5,281 1,379 205,223 50-54 147,053 26,180 5,866 2,048 4,333 1,041 186,521 55-59 116,137 17,511 3,882 1,262 2,973 762 142,527 60-64 94,696 12,098 3,065 950 2,325 609 113,743 65-69 83,881 8,813 2,372 586 1,762 440 97,854 70-74 81,367 6,635 1,712 364 1,290 326 91,694 75-79 72,362 4,450 1,215 312 826 247 79,412 80-84 50,794 2,542 808 161 436 136 54,877 85+ 39,911 1,918 665 147 341 149 43,131 TOTAL 2,091,450 829,443 115,913 50,730 76,137 37,171 3,200,844 F. Table 8- MC Population, 2002, by Age and Race Per U.S. Census Bureau White Hispanic Black 0-4 123,416 112,615 10,876 5-9 124,653 99,304 10,931 10-14 131,472 84,673 11,375 15-19 123,926 72,420 10,155 20-24 130,263 92,792 9,238 25-29 133,466 95,610 9,394 30-34 155,953 82,042 9,984 35-39 160,734 66,382 10,117 40-44 174,407 51,955 9,959 45-49 159,376 38,256 8,025 50-54 147,511 28,140 6,292 55-59 127,243 19,406 4,260 60-64 100,095 13,102 3,242 65-69 84,278 9,472 2,573 70-74 80,803 6,934 1,778 75-79 72,065 4,793 1,304 80-84 52,707 2,814 844 85+ 41,717 2,064 709 TOTAL 2,124,085 882,774 121,056 Native Asian/Pacific American Islander Other Total 5,076 6,152 7,043 265,178 4,810 5,655 6,196 251,549 4,979 5,065 4,890 242,454 4,548 4,755 3,722 219,526 5,650 5,694 3,245 246,882 5,454 8,912 2,564 255,400 4,811 9,434 2,367 264,591 4,101 7,517 1,960 250,811 3,741 6,775 1,835 248,672 2,602 5,672 1,448 215,379 2,106 4,642 1,101 189,792 1,420 3,350 855 156,534 956 2,501 677 120,573 626 1,983 460 99,392 405 1,398 354 91,672 325 887 251 79,625 189 529 145 57,228 162 365 150 45,167 51,961 81,286 39,263 3,300,425 49 F. Table 9-MC Population, 2003, by Age and Race Per U.S. Census Bureau Asian/Pacific Native White Hispanic Black Other Total American Islander 0-4 125,547 120,296 11,370 5,244 6,694 7,323 276,474 5-9 124,379 102,909 11,139 4,777 5,935 6,600 255,739 10-14 132,065 90,712 11,768 5,092 5,368 5,138 250,143 15-19 125,888 74,315 10,612 4,691 4,822 3,968 224,296 20-24 131,903 92,767 9,744 5,508 5,637 3,453 249,012 25-29 133,580 101,766 9,427 5,594 9,008 2,778 262,153 30-34 154,760 87,521 10,314 5,013 10,195 2,473 270,276 35-39 157,137 70,925 10,137 4,149 8,006 2,002 252,356 40-44 175,335 55,804 10,341 3,819 7,009 1,937 254,245 45-49 165,356 41,413 8,428 2,737 6,108 1,590 225,632 50-54 149,482 30,209 6,709 2,178 5,040 1,188 194,806 55-59 134,416 21,250 4,631 1,551 3,671 923 166,442 60-64 107,405 14,384 3,540 1,010 2,655 768 129,762 65-69 86,461 10,073 1,271 702 2,189 1,912 102,608 70-74 79,793 7,268 1,903 408 1,502 341 91,215 75-79 72,261 5,118 1,359 348 989 272 80,347 80-84 54,046 2,987 899 200 556 165 58,853 85+ 44,303 2,353 756 169 429 147 48,157 TOTAL 2,154,117 932,070 124,348 53,190 85,813 42,978 3,392,516 50 F. Table 10-MC Population, 2004, by Age and Race Per U.S. Census Bureau 0-4 5-9 10-14 15-19 20-24 25-29 30-34 35-39 40-44 45-49 50-54 55-59 60-64 65-69 70-74 75-79 80-84 85+ TOTAL Asian/Pacific Native White Hispanic Black Other Total American Islander 127,998 127,931 12,093 5,481 7,269 7,609 288,381 125,262 107,870 11,448 4,864 6,202 6,973 262,619 132,327 96,472 12,342 5,167 5,740 5,577 257,625 128,754 77,846 11,128 4,888 5,007 4,193 231,816 132,431 91,657 10,434 5,378 5,720 3,654 249,274 138,200 107,745 9,922 5,821 9,169 3,154 274,011 152,773 93,769 10,701 5,075 10,802 2,595 275,715 155,720 75,339 10,311 4,206 8,597 2,077 256,250 177,828 60,467 10,766 4,046 7,625 1,997 262,729 170,123 45,013 9,025 2,912 6,455 1,708 235,236 153,634 32,584 7,156 2,314 5,400 1,308 202,396 142,787 23,526 5,116 1,706 4,103 1,019 178,257 114,730 15,772 3,762 1,050 2,903 798 139,015 89,569 10,811 2,837 790 2,343 580 106,930 79,177 7,706 2,060 463 1,663 374 91,443 71,946 5,439 1,418 356 1,088 289 80,536 55,973 3,258 964 218 628 193 61,234 46,456 2,585 803 203 486 143 50,676 2,195,688 985,790 132,286 54,938 91,200 44,241 3,504,143 51 F. Table 11-MC Population, 2005, by Age and Race Per U.S. Census Bureau Native Asian/Pacific White Hispanic Islander Other Black American Total 0-4 131,677 136,732 13,096 6,168 8,239 8,125 304,037 5-9 126,513 114,259 12,201 4,989 6,598 7,475 272,035 10-14 132,779 102,902 12,887 5,242 6,216 5,985 266,011 15-19 131,494 83,782 11,850 5,215 5,339 4,588 242,268 20-24 133,199 90,496 10,839 5,350 5,921 3,871 249,676 25-29 144,183 114,068 10,949 6,159 9,421 3,407 288,187 30-34 149,574 101,693 10,804 5,212 11,348 2,697 281,328 35-39 158,240 81,547 10,988 4,348 9,693 2,268 267,084 40-44 178,687 65,745 11,160 4,242 8,380 2,156 270,370 45-49 176,527 49,750 9,890 3,130 7,018 1,806 248,121 50-54 159,798 35,640 7,776 2,462 5,843 1,447 212,966 55-59 152,499 26,202 5,680 1,954 4,685 1,149 192,169 60-64 121,749 17,584 4,195 1,125 3,250 889 148,792 65-69 93,149 11,692 3,079 862 2,584 624 111,990 70-74 79,048 8,314 2,192 507 1,812 409 92,282 75-79 72,515 5,889 1,570 369 1,284 306 81,933 80-84 57,360 3,553 1,024 273 691 205 63,106 85+ 49,489 2,916 875 213 564 157 54,214 TOTAL 2,248,480 1,052,764 141,055 57,820 98,886 47,564 3,646,569 52 F. Table 12-MC Population, 2006, by Age and Race Per U.S. Census Bureau Native Asian/Pacific White Hispanic Islander Black American Other Total 0-4 132,260 144,480 14,056 6,408 8,940 8,598 314,742 5-9 128,715 122,574 13,338 5,190 7,482 7,787 285,086 10-14 132,488 109,537 13,365 5,242 6,778 6,556 273,966 15-19 133,301 89,898 12,591 5,535 5,703 4,929 251,957 20-24 132,580 89,518 11,555 5,283 6,177 4,122 249,235 25-29 149,249 119,813 11,751 6,471 9,771 3,678 300,733 30-34 144,085 109,317 11,405 5,291 12,156 2,808 285,062 35-39 162,766 88,738 11,506 4,668 10,953 2,499 281,130 40-44 175,993 71,214 11,800 4,369 9,049 2,242 274,667 45-49 181,341 54,447 10,639 3,374 7,667 1,956 259,424 50-54 164,687 38,961 8,310 2,556 6,451 1,607 222,572 55-59 161,916 28,900 6,446 2,133 5,236 1,247 205,878 60-64 127,309 19,346 4,537 1,230 3,656 962 157,040 65-69 97,665 12,840 3,333 934 2,833 695 118,300 70-74 79,506 8,907 2,411 578 1,996 456 93,854 75-79 72,423 6,320 1,670 377 1,437 318 82,545 80-84 57,961 3,889 1,116 300 826 230 64,322 85+ 52,742 3,286 972 246 667 172 58,085 Total 2,286,987 1,121,985 150,801 60,185 107,778 50,862 3,778,598 53 F. Table 13-MC Population, 2007, by Age and Race Per U.S. Census Bureau Native Asian/Pacific White Hispanic Black American Islander Other Total 0-4 133,134 151,414 14,712 6,310 9,352 8,939 323,861 5-9 129,505 129,287 14,216 5,352 8,100 7,949 294,409 10-14 131,286 115,090 13,762 5,225 7,304 6,979 279,646 15-19 134,089 95,991 13,338 5,684 6,044 5,321 260,467 20-24 131,584 89,365 11,954 5,329 6,021 4,165 248,418 25-29 150,746 122,531 12,595 6,400 9,893 3,996 306,161 30-34 141,215 115,483 11,684 5,587 12,548 2,901 289,418 35-39 163,131 95,446 12,248 4,784 12,091 2,675 290,375 40-44 170,559 75,747 11,910 4,374 9,497 2,296 274,383 45-49 184,165 59,087 11,265 3,659 8,237 2,102 268,515 50-54 169,743 42,643 8,954 2,713 6,945 1,717 232,715 55-59 161,787 31,104 6,954 2,193 5,637 1,302 208,977 60-64 137,642 21,361 4,931 1,411 4,060 1,056 170,461 65-69 103,962 13,997 3,539 955 3,046 778 126,277 70-74 80,592 9,623 2,639 625 2,237 485 96,201 75-79 72,468 6,638 1,741 426 1,556 351 83,180 80-84 58,124 4,233 1,211 298 914 237 65,017 85+ 55,815 3,616 1,035 280 764 190 61,700 TOTAL 2,309,547 1,182,656 158,688 61,605 114,246 53,439 3,880,181 54 F. Table 14-MC Population, 2000-2007, by Age and Race Per U.S. Census Bureau 0-4 5-9 10-14 15-19 20-24 25-29 30-34 35-39 40-44 45-49 50-54 55-59 60-64 65-69 70-74 75-79 80-84 85+ White Hispanic Black 1,015,072 996,300 96,099 1,009,489 857,707 94,554 1,049,133 750,371 96,763 1,022,216 637,109 88,645 1,038,905 718,711 80,848 1,125,151 831,701 82,226 1,203,073 733,459 83,709 1,291,188 597,517 85,151 1,389,520 471,529 84,460 1,338,111 354,372 71,758 1,228,669 257,644 56,276 1,106,820 183,545 40,627 893,536 124,604 30,172 723,121 86,023 21,218 642,069 61,614 16,359 578,032 42,687 11,422 435,036 25,493 7,591 367,657 20,437 6,464 TOTAL 17,456,798 7,750,823 1,054,342 Native Asian/Pacific American Islander Other Total 44,161 57,364 60,834 2,269,830 39,534 49,920 53,960 2,105,164 40,303 45,668 43,714 2,025,952 39,455 40,760 33,606 1,861,791 43,513 46,316 28,236 1,956,529 46,177 73,112 24,496 2,182,863 40,087 82,502 20,042 2,162,872 34,357 70,786 17,394 2,096,393 31,223 60,415 15,814 2,052,961 23,242 51,237 13,314 1,852,034 18,225 42,473 10,441 1,613,728 13,358 32,243 8,003 1,384,596 8,589 23,436 6,339 1,086,676 5,976 18,366 5,923 860,627 3,709 13,069 3,081 739,901 2,792 8,749 2,268 645,950 1,782 4,956 1,443 476,301 1,553 3,902 1,244 401,257 438,036 725,274 350,152 27,775,425 G. 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