Publication of the Division of Public Health Services Table of Contents Diabetes in Arizona Page 3 Pandemic or Seasonal Influenza & Influenza Update Page 4 January/February 2006, Vol. 20, No. 1 What is the Best CPR? “Getting to the Heart of the Matter” By Ben Bobrow, MD and Lani Clark RSV Activity in Arizona Page 5 The recent release and media coverage of the American Heart Association 2005 Adult Basic Life Support (BLS) and Advanced Cardiac Life Support (ACLS) guidelines has peaked interest in the question as to what is the optimal method for performing life sustaining cardiopulmonary resuscitation (CPR) and defibrillation for cardiac arrest victims. NoteWorthy Page 6 Outcome Depends on Intervention: The State Epi's Corner Page 5 New Year's Resolutions Page 7 New Recommendations for Use of Antivirals to Treat or Prevent Influenza in the 2005-2006 Season Visit the ADHS Web site at www.azdhs.gov January/February 2006 Cardiac arrest remains a significant cause of mortality, accounting for more than a thousand deaths a day in the United States alone. With current health care delivery systems in place, survival to hospital discharge remains extremely poor with estimates at or below 5%. In many of the nation’s largest cities, neurologically intact survival is as low as 1%. Outcome after cardiac arrest is dependent on critical interventions; particularly effective chest compressions, early defibrillation, and advanced life support (AHA Scientific Statement 2004). The reasons for the dismal survival rates are many but two major contributing factors are the lack of bystander initiated CPR, and the apparent under utilization of AEDs by the lay public. Both of these have been clearly documented in the state of Arizona through instituting a statewide cardiac arrest and AED registry termed the Save Hearts in Arizona Registry & Education (SHARE) Program. The Key to Survival: Ventricular Fibrillation (VF), a potentially treatable dysrhythmia, remains the underlying cause in a majority of these cases, and early defibrillation has shown to significantly increase survival. However, defibrillation is not always immediately available and thus CPR is required to support the victim’s brain and heart with vital oxygen until a defibrillator arrives. Thus the combination of CPR and AED use is key to survival from out of hospital cardiac arrest. The lack of bystander initiated CPR (currently 65% of cardiac arrest victims in Arizona receive no bystander CPR) can potentially be overcome in our state and globally by teaching chest-compression-only, or continuous chest compression CPR (CCC-CPR). Chest compression only CPR has been shown in animals to be dramatically better than no bystander CPR and even better than mouth-to-mouth rescue breathing when chest compressions were interrupted for a realistic 16 seconds for rescue breathing. Because time to defibrillation remains a critical element in a successful resuscitation, the Automated External Defibrillator (AED) was developed to broaden the pool of available rescuers. The addition of AED training to CPR training in lay volunteers has shown superior survival benefit to conventional CPR training alone. Several studies have even demonstrated that very young previously untrained children can be taught to successfully operate an AED. Continued on page 2 1 What is the Best CPR? Continued from page 1 In fact, in 2005, a collaborative research study conducted by the Mayo Clinic and the SHARE Program clearly showed that 8th grade Arizona public school students can safely and efficiently be taught and retain the skills to properly perform CCC-CPR and AED use in a condensed 1-hour course on campus. What Have We Learned About CPR? To be successful, CPR must be started as soon as a victim collapses, thus it is the public that MUST know to call 9-1-1 immediately, then perfrom effective chest compressions and use an AED. We have learned that when these events occur in a timely manner, CPR makes a difference and saves lives. We have also learned that chest compressions are the vital component of CPR that many times are interrupted too frequently and performed in a suboptimal fashion. New Developments: The new AHA 2005 Guidelines have increased emphasis on the importance of chest compressions: “Rescuers will be taught to “push hard, push fast” (at a rate of 100 compressions/min), allow complete chest recoil, and minimize interruptions in chest compressions.” SHARE Program: The SHARE Program is a voluntary, statewide, HIPAA compliant cardiac arrest network and database for out-of-hospital cardiac arrest and AEDs in Arizona. Since 2004, the SHARE Program has partnered with over 20 Fire Departments and private ambulance companies in every Region of Arizonaand the Sarver Heart Center CPR Research Group to build this essential statewide cardiac arrest network. The SHARE AED database currently tracks over 2,500 AEDs (and who is trained on each site to use them) in Arizona. These databases are showing the times and places when cardiac arrest occurs, if bystander CPR is performed, not performed, or could be improved upon along with many other vital data points. The Bureau of Emergency Medical Services is also working with research teams looking at cardiac arrest all over North America. The focus of the SHARE Program this coming year is on continuing to expand the infrastructure for collecting pre hospital cardiac arrest data from EMS providers across the state and track their survival utilizing an algorithm of providing pre and post shock chest compressions for adult VF victims. This data is helping to determine the optimal sequence of interventions for advanced cardiac life support along other potential new treatments that will improve cardiac arrest survival in Arizona and globally. Ben Bobrow, MD is Medical Director for the Bureau of EMS and Lani Clark is Research and QI Director for the Bureau of EMS. For more information visit the www.azshare.gov website. REFERENCES: John J, Ewy G. Cardiopulmonary Resuscitation: A New Paradigm is Needed, Arizona Geriatrics Society, 2005; 10:3: 3-8 AHA Scientific Statement 2004 Cardiac Arrest Resuscitation Evaluation in Los Angeles: CARE-LA Annals of Emergency Medicine. May 2005:45: 504-509. Kern KB, Hilwig RW, Berg RA, Sanders AB, Ewy GA. Importance of Continuous Chest Compressions During Cardiopulmonary Resuscitation, Circulation 2002:105:645-649. The Public Access Defibrillation Trial Investigators: Public Access Defibrillation and Survival after out of Hospital Cardiac Arrest. N Engl J Med 351:7:637646. Lawson L, March J: Automated External Defibrillation by Very Young Untrained Children. Prehosp Emerg Care, July-Sept 2002:6(3):295-8 Hubble MW, Bachman M, Price R. Willingness of High School Students to Perform Cardiopulmonary Resuscitation and Automated External Defibrillation. Prehosp Emerg Care, Apr-Jun 2003:7(2):219-224. Eighth Grade Public School Students Become Proficient at CPR and AED Use After a Condensed Training Program Presented at the Third Mediterranean Emergency Medicine Conference, Nice, France. September, 2005. Journal of the American Heart AssociationCirculation Vol 112, No 24, December, 13, 2005 2 Diabetes In Arizona by Magda Ciocazan, M.P.H. manage diabetes are maintaining direction for control efforts throughDiabetes will place an immense a healthy weight (BMI 18.5-25), toll on Arizona’s various health out the state. adequate exercise, proper nutrition care delivery systems in the next The Diabetes in Arizona: 2005 (especially consumption decade. According Status Report examines the burden of high fiber and low to the 2004 BRFSS of diabetes and its complications fat foods) and eliminatdata, 6.6 percent in the state of Arizona. This docuof Arizonan adults, ing the use of tobacco ment will be placed on the ADHS or approximately and alcohol. Managing Diabetes Prevention and Control 284,102, have stress, keeping hydrated web site by the end of January been told by a and adequate rest also 2006. This report, as well as other doctor they have helps prevent diabetes annual and county specific reports diabetes, and an and associated complifor diabetes, can be accessed under additional 1.2 cations in those most the Resources: Annual Reports link percent of women at risk. Successful manat the following web site: www. have gestational agement of diabetes azdhs.gov/phs/oncdps/diabetes diabetes. requires improvement in physician practices, In 2004, there 1. Harris MI, Flegal KM, Cowie CC, Eberhardt MS, Goldstein DR, Little RR, Wiedmeyer H, Byrd-Holt DD. modification of health were more than Prevalence of diabetes, impaired fasting glucose, and care delivery systems, 91,000 people impaired glucose tolerance in US adults. Diabetes Care. 1998;21(4):518-524. new societal attitudes hospitalized due regarding nutrition and to diabetes, with Magda Ciocazan, M.P.H., is the Diabetes physical activity, and the empowhospital charges amounting to more Prevention and Control Program Manager, than $2.5 billion. According to the erment of patients who must take Office of Chronic Disease Prevention and American Diabetes Association, charge of their disease. Nutrtition Services, and can be reached at 602.542.2758 or ciocazam@azdhs.gov. type 2 diabetes is being diagnosed The ethnic diversity of Arizona chalmore frequently than ever before in lenges our health care agencies in children and adolescents, particuregards to comprehensive data collarly in American Indians, Hispanic/ lection data and effective program Estimated Number of Latino Americans, and African development. With the help of its Americans. However, it is difficult Self-Identified Diabetics partners, the Arizona Department to obtain exact figures for diabetes by County, 2004 of Health Services (ADHS) conprevalence, because there is no sysSource: Arizona BRFSS, 2004. tinues to monitor diabetes indicatematic collection of information on tors to determine the appropriate the number of cases. Additionally, County Total studies have Apache 2,911 shown that Prevalence of Diabetes in Arizona, about one-third Cochise 6,369 2000-2004 of all people Coconino 6,129 Source: Arizona BRFSS, 2000-2004. with diabetes Gila 2,688 have not been 1 diagnosed. Graham 1,671 DIABETES PREVALENCE RATE Due to the increase of obesity, physical inactivity, and poor nutrition in Arizona, the prevalence of diabetes is also increasing. The main lifestyle factors that help prevent and BY AGE GROUP 16 14 .3 14 1 0 .5 12 10 8 .1 8 6 4 2 3.2 1.2 0 1 8 -3 4 3 5 -4 4 4 5 -5 4 Age Group 5 5 -6 4 65+ Greenlee La Paz Maricopa Mohave Navajo Pima Pinal Santa Cruz Yavapai Yuma Arizona 378 1,108 170,895 9,196 4,605 46,586 10,855 1,850 10,298 8,563 284,102 3 Pandemic or Seasonal Influenza: Infection Control in Outpatient Settings Of late, the news has been filled with discussions of a pandemic influenza. Most experts seem to agree that we are likely to face another pandemic; however, many scientific questions about the pandemic remain unanswered - when will it occur, how severe will it be, or will H5N1 be the causal agent? Yet, we do know that every year in the United States, on average 5% to 20% of the population gets the flu, more than 200,000 people are hospitalized for flu-related conditions and 36,000 deaths occur from complications of the flu. Thus, irrespective of whether it is seasonal flu, or pandemic flu, prevention and control measures need to be in place in health care facilities to minimize the spread of flu and other respiratory infections and the associated burden of disease and death. Outpatient clinical settings are prime locations for spread of infectious diseases. Despite some possible differences between seasonal and pandemic flu in terms of incubation period, immunogenicity, mechanisms of spread and pathogenesis, at this time the primary strategies for preventing both are the same: vaccination, early detection and treatment, and the implementation of infection control measures. Vaccination remains the primary strategy for preventing infection and disease; health care personnel is one the groups for which vaccination is highly recommended. More information is available at www.cdc.gov/flu/ protect/keyfacts.htm and www.jfponline.com/Pages asp?AID=1727&UID by Victorio Vaz Since a vaccine may not be available at the onset of the pandemic, flu containment will hinge upon appropriate infection control measures in place. To that end: • Surveillance for respiratory illness is needed to limit contact between infected and non-infected patients through confinement in defined areas and/or by encouraging social “distancing”, i.e., at least three feet apart. • Respiratory hygiene/cough etiquette should be promoted at the first point of contact with a potentially infected patient through posting visual alerts, providing tissues, no-touch receptacles for tissue disposal and masks for patients and visitors who are coughing or sneezing, ensuring hand washing sinks with soap and disposable towels and/or alcohol-based hand sanitizers, and encouraging coughing persons to sit at least 3 feet away from others: www.cdc.gov/flu/professionals/infectioncontrol/resphygiene.htm. • Hand hygiene between patients and after contact with respiratory secretions need to be adhered to. Personal protective equipment (PPE) should be used for standard and droplet precautions. Further information on the selection and use of PPE can be found at www.cdc.gov/ncidod/dhqp/gl_isolation_standard.html and www.cdc.gov/ncidod/dhqp/ gl_isolation_droplet.html. Influenza Season Update Influenza activity broke with tradition during the 2005-206 season by starting in the western part of the United States. Frequently, high activity is noted first in the eastern states, followed by a westward sweep across the county. This year, Utah was the first state to report widespread activity (week ending December 17, 2005). Two weeks later, the entire southwest corner of the U.S. (7 states) reported widespread activity, with all other states reporting lower levels. Now, at the end of January, activity levels are decreasing in the western U.S. and other states are reporting increased levels. Arizona first reported widespread activity the week ending December 24, 2005, and continued to report widespread activity until dropping to regional activity on January 23, 2006. This is earlier than Arizona’s typical peak season. These activity levels are determined by reports of influenza-like illness from sentinel providers around the state, mandatory laboratory reporting of positive influenza tests, and other surveillance conducted by county health departments. A decrease in statewide activity does not indicate that influenza season is over; some regions of the state may continue to see influenza for weeks or months. Reports of laboratory-confirmed influenza for the season are shown in the figure. During most influenza seasons, including last year’s, there is a mix of influenza A and influenza B circulating in the community. This season the circulating strain so far has overwhelmingly been influenza A, with this strain accounting for over 95% of cases in both Arizona and the U.S. as a whole. Arizona influenza surveillance data are available on the internet at www.azdhs.gov/phs/oids/epi/flu/az_flu_surv.htm and are updated weekly. 4 Another One Bites the Dust… As detailed in the current issue of Prevention Bulletin, CDC announced on January 14, 2006 that the adamantane influenza antivirals are no longer recommended for treatment of influenza during the 2005-2006 flu season, because of an alarming 91% level of David Engelthaler, resistance (1). Resistance has State Epidemiologist become a four-letter word in both the clinical and public health communities. Antibiotic resistance has forced the medical world to develop complex algorithms and alternative therapies to respond to bacterial infections. And although antiviral-resistance has been a threat, until now we have not seen a nearly complete evasion of an antiviral therapy. Whether this adamantane resistance is use-induced (conferred by use of and subsequent adaptation to adamantanes) or is from a natural mutation in the current flu strains circulating this season, it is still one of the more disconcerting pieces of news this year. Time will tell us if adamantine-resistance is an ephemeral event, based on the genetics of the circulating strains, or if it confers evolutionary advantage to human influenza strains, and will therefore likely be a constant adaptation. Additionally, one can only speculate about the future of the remaining anti-influenza drugs - the neuraminidase inhibitors (oseltamivir and zanamivir). Resistance has been documented in children treated with oseltamivir(2), and various reports have documented varying levels of resistance to oseltamivir by the H5N1 avian influenza virus causing incidental human infections in Asia and Eastern Europe (3,4). These unfortunate reports force us to consider resistance when responding to our annual flu outbreak as well as in the face of pandemic preparedness. A few things we should take from this news: a) Health care providers need to continue to focus on prevention of disease and transmission – encourage flu shots to all patients, and continue to promote respiratory etiquette and hand washing as a way of life b) Proper diagnosis and reporting (influenza is a laboratory reportable condition in Arizona) of illness will help not only to better understand to epidemiology of the annual flu season, but will help identify any resistance to antiviral therapies c) Antivirals are only one tool to help fight influenza (seasonal or pandemic) but their overall effectiveness is tentative, and may be fleeting. This should affect how we respond now and prepare for the future. 1. 2. 3. 4. CDC Health Alert Jan 14, 2006 Kiso M, Mitamura K, Sakai-Tagawa Y, et al. Lancet 2004;364:759-765. N Engl J Med. 2005 Dec 22;353(25):2633-6. Dr. Anthony Fauci, Dec 5, 2005, Pandemic Planning: Convening of the States, Washington D.C. RSV Activity in Arizona 2005-2006 by Karen Lewis, M.D. & Shoana Anderson Respiratory Syncitial Virus (RSV) became a laboratory-reportable disease in October 2004. Arizona laboratories now report positive RSV tests to the Arizona Department of Health Services (ADHS) on a weekly basis. With this new information, ADHS can let providers know when Arizona is experiencing an increase in RSV isolates. Historically, the RSV season in Arizona begins between October and December. Although there are sporadic isolates of RSV throughout the year, once there begins to be an increase in RSV infections in the fall or early winter, the number of RSV cases rapidly increases and high numbers of RSV infections continue for several months. RSV cases in Arizona began to be reported sporadically in the middle of October 2005. In November, ADHS notified health care providers to expect to see increasing RSV activity. RSV was reported steadily throughout December, and reports escalated at the end of December. As of January 14, 2006, there had been 246 laboratory confirmed cases of RSV in Arizona. Monitoring RSV activity in Arizona can assist health care providers who provide RSV immunoglobulin injections to high-risk infants. In November 2005, when ADHS received increasing reports of RSV in Arizona, ADHS sent out electronic notification to health care providers to assist them with their plans for RSV immununoglobulin administration. Conversely, once RSV activity starts to slow in the state, ADHS will send electronic notification to health care providers about the decrease in RSV cases. Providers will benefit by having real time data to help decide when to stop monthly RSV immunoglobulin injections. RSV cases are expected to remain high in January and February. The tally for RSV cases reported in Arizona is posted weekly at the ADHS web site at www. azdhs.gov/phs/oids/epi/flu/az_flu_surv.htm along with influenza surveillance information. Numbers of new RSV and influenza cases are updated every Monday. Karen Lewis, M.D. is Medical Director, Bureau of Epidemiology and Disease Control and can be reached at 602.364.4562. 5 2004 Infectious Disease Epidemiology Annual Report Available Online Want more information on our record high number of reported cases of coccidioidomycosis in 2004? Or 20 year low rates of reported shigellosis cases? The 2004 Infectious Disease Epidemiology Annual Report is now available online at www.azdhs.gov/phs/oids/ reports.htm. The report includes statistics on communicable diseases, outbreak investigations, and an evaluation of recent trends in infectious diseases in Arizona. Hurricane Katrina Arizona Epidemiology Report Posted on the ADHS Web site As part of the response activities to Hurricane Katrina, Arizona housed and provided medical care to over 800 hurricane evacuees. Analysis of available clinic data indicated that one of the primary reasons for medical visits were lost medications/personal health items, followed by gastrointestinal and respiratory symptoms. Surveillance activities identified no major infectious disease outbreaks among shelter residents. The Infectious Disease Epidemiology Program prepared a report on the health status and epidemiology of evacuees seen at the Red Cross shelter medical clinic. The entire report can be viewed at www.azdhs.gov/phs/oids/pdf/adhs_ katrina_epi_report.pdf Joint Vector-Borne/Zoonotic Diseases and Bioterrorism/ Public Health Threats Conference: March 29-30, 2006; Glendale Civic Center, 5750 West Glenn Drive, Glendale, AZ 85301 Presented by: ADHS 30th Annual Vector-Borne and Zoonotic Diseases Conference With emerging disease threats like Rocky Mountain spotted fever, West Nile virus and possibly Avian influenza, the need to prepare and respond to vector-borne and zoonotic diseases has never been greater. This conference will feature a combination of local, state and federal experts to present the latest updates on vector-borne and zoonotic diseases in the Southwest. 6th Annual Bioterrorism and Public Health Threats Conference This conference provides the opportunity to learn about an important emerging threat: pandemic influenza. Various aspects of local and national pandemic influenza preparedness efforts will be addressed. You can register for the conference online by visiting: http://www.azdhs.gov/phs/edc/ edrp/es/conf.htm Amantadine and Rimantadine Should Not Be Used for Influenza This Winter by Karen Lewis,M.D. On January 14, 2006, the Centers for Disease Control and Prevention (CDC) announced that clinicians should not use amantadane antivirals (amantadine or rimantadine) to treat or prevent influenza during the remainder of the 2005-2006 influenza season. Tests on influenza A (H3N2) isolates, the predominant strain currently circulating in the United States, show that they are resistant to both amantadine and rimantadine. CDC tested 120 influenza A (H3N2) virus isolates from the 2005-2006 season and found that 91% were resistant to both amantadine and rimantadine. This contrasts with last year when only 14.5% of isolates tested were resistant; the previous year, 1.9% were resistant. The global prevalence of adamantane-resistant influenza viruses has increased from 1.9% to 12.3% over the past 3 years. Fortunately, all H3 and H1 influenza viruses tested to date in the United States are still susceptible to the neuraminidase inhibitors (oseltamivir [Tamiflu®] and zanamivir [Relenza®]). Therefore, if an antiviral medication is needed this season for influenza, CDC recommends that either oseltamivir (Tamiflu®) or zanamivir (Relenza®) be prescribed. Oseltamivir is approved for either treatment or prophylaxis; zanamivir is approved only for treatment. Since amantadine is used to treat the symptoms of Parkinson’s disease, it should continue to be used for this indication. Viral resistance to adamantanes can emerge rapidly during treatment because a single point mutation of an amino acid can confers cross-resistance to both amantadine and rimantadine. Adamantane-resistant viruses are equally as transmissable as adamantane-sensitive viruses. Additional information about the prevention and control of influenza is available at www.cdc.gov/flu. Specific information regarding the use of the neuraminidase inhibitors is available at http://www.cdc.gov/flu/protect/ antiviral. Karen Lewis,M.D.is Medical Director,Bureau of Epidemiology and Disease Control and can be reached at 602.364.4562 or lewisk@azdhs.gov. 6 Arizona Department of Health Services Public Information Office 150 North 18th Avenue Phoenix, AZ 85007 Janet Napolitano, Governor Susan Gerard, Director ADHS Niki O’Keeffe, Assistant Director, Public Health Services Contributors: Shoana Anderson Ben Bobrow, MD Lani Clark Eric Day, M.B.A. Lisa DeMarie, M.A. David Engelthaler, Will Humble M.P.H., Bob Gomez, R.S., M.P.H., Karen Lewis, M.D., Victorio Vaz, M.D., Tthe Office of Infectious Disease Services, The Arizona Immunization Program Office, The Office of HIV/AIDS Services Managing Editor: Mary Ehlert, M.S., ABC e-mail: ehlertm@azdhs.gov This publication is supported by the Preventive Health and Health Services Block Grant from the Centers for Disease Control and Prevention (CDC). Its contents do not necessarily represent the views of the CDC. If you need this publication in alternative format, please contact the ADHS Public Information Office at 602.364.1201 or 1.800.367.8939 (State TDD/TTY Relay). Strategies to Help Your Patients Keep New Year’s Resolutions and Live Healthier Lives For many people the New Year is a time to make health-related resolutions. Whether it’s to lose weight, control stress, or adopt healthier eating habits, such resolutions can be difficult to keep. However, working toward these and other goals can improve a person’s health. Setting realistic goals year round - and not just at the beginning of the New Year - can lead to a healthier lifestyle, improved self-esteem, and increased confidence. 1. Don’t try everything at once. The temptation of the New Year is to create a list of everything a person has ever wanted to change. Generally, your patients will experience greater success fulfilling one or two goals than they will a list of ten. If eating healthier and getting more physical activity is their goal, ask them to start small. For example, if your patient is currently drinking whole milk, suggest they switch to 2% and work gradually towards 1%. For physical activity, have your patients identify one activity that they enjoy, such as walking or biking, and encourage them to be consistent with this activity. 2. Be specific. When your patients think about their goal, ask them to be as exact as possible. People who set specific goals are more likely to succeed. For example, instead of saying “I will drink more water”, suggest they set a specific goal to drink 6-8 glasses of water a day. If your patient’s goal is to add more physical activity into their day, encourage them to set a goal of using the stairs instead of the elevator or taking a 10mintue walk break every day. 3. Set realistic goals. When your patients think about setting goals, make sure that they are within their reach. For instance, if they currently lead a sedentary lifestyle, have them begin by incorporating three 10-minute bouts of a physical activity, such as walking, per day. For better eating habits, one example might be to not eliminate an entire food group entirely, such as grains, but to instead try consuming whole grains such as oats, whole wheat breads and pasta and brown rice into their meals. January/February 2006 by Lisa DeMarie, M.A. and Eric Day, M.B.A. 4. Believe it can be done, be flexible and remember rewards. Stay positive about a patient’s progress. Keep in mind that setbacks can happen, and if patients slip up, encourage them to keep trying. Acknowledge their achievements, even the small ones. Remind patients that their reward should not interfere with their overall goal. For example, treating yourself to your favorite movie is a more effective reward than an ice cream cone for sticking with a healthy diet. Resources for Professionals and Patients: http://www.mypyramid.gov http://www.nhlbi.nih.gov/health/public/ heart/obesity/lose_wt/index.htm http://www.healthierliving.org/newsletter/ 200201/resolve.html http://family.samhsa.gov/be/goals.aspx Lisa DeMarie, M.A., is the Nutrition and Physical Activty Program Manager, Office of Chronic Disease Prevention and Nutrition Services, and can be reached at 602.542.2851 or demaril@azdhs.gov. Eric Day, M.B.A., is the Physical Activity Coordinator, Office of Chronic Disease Prevention and Nutrition Services, and can be reached at 602.364.2804 or daye@azdhs.gov. 7